PMID: 9182855Jan 1, 1997Paper

Expression of estrogen receptor exon 5 splicing variant (ER E5SV) mRNA in gynaecological cancers

The Journal of Steroid Biochemistry and Molecular Biology
J FujimotoT Tamaya

Abstract

Estrogen receptor exon 5 splicing variant (ER E5SV) mRNA has been found in tumours and the corresponding normal tissues, being transcriptionally active without ligand binding. Therefore, the expression of ER E5SV mRNA in gynaecological cancers was studied. The presence of ER E5SV mRNA was demonstrated in the normal ovary, uterine endometrium and cervix and their corresponding cancers. The ratio of ER E5SV/ER WT mRNA expression increased in some cases of metastatic tumour, but did not decrease in any case. Relative overexpression of ER E5SV mRNA might contribute to dominant positive properties and metastatic potential. Therefore, detection of ER E5SV mRNA abundance might be a useful indicator of metastatic potency in gynaecological cancers.

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Citations

Mar 18, 1999·Hematology/oncology Clinics of North America·G Emons, J J Kavanagh
Nov 1, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J FujimotoT Tamaya
Apr 3, 2001·The Journal of Steroid Biochemistry and Molecular Biology·J FujimotoT Tamaya
Apr 25, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Jiro FujimotoTeruhiko Tamaya
Oct 21, 1998·The Journal of Steroid Biochemistry and Molecular Biology·K MitoH Honjo
Jun 16, 1999·The Journal of Steroid Biochemistry and Molecular Biology·R MisaoT Tamaya
Jul 18, 2009·Cancer Letters·Siân E TaylorFrancis L Martin
Mar 17, 2000·The Journal of Clinical Endocrinology and Metabolism·S ChuP J Fuller
Mar 1, 2011·Hormone Molecular Biology and Clinical Investigation·Jiro Fujimoto, Eriko Sato

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