Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia.

Journal of Neuroscience Research
Siok L DunNae J Dun

Abstract

The G protein-coupled receptor GPR30 has recently been identified as a nonnuclear estrogen receptor. Reverse transcriptase-polymerase chain reaction revealed expression of GPR30 mRNA in varying quantities in the rat spinal cord, dorsal root ganglia, nodose ganglia, trigeminal ganglia, hippocampus, brain stem, and hypothalamus. Immunohistochemical studies that used a rabbit polyclonal antiserum against the human GPR30 C-terminus revealed a fine network of GPR30-immunoreactive (irGPR30) cell processes in the superficial layers of the spinal cord; some of which extended into deeper laminae. A population of neurons in the dorsal horn and ventral horn were irGPR30. Dorsal root, nodose, and trigeminal ganglionic neurons displayed varying intensities of irGPR30. Positively labeled neurons were detected in the major pelvic ganglion, but not in the superior cervical ganglion. A population of chromaffin cells in the adrenal medulla was irGPR30, so were cells of the zona glomerulosa. Double-labeling the adrenal medulla with GPR30 antiserum and tyrosine hydroxylase antibody or phenylethanolamine-N-methyltransferase antiserum revealed that irGPR30 is expressed in the majority of tyrosine hydroxylase-positive chromaffin cells. Last, some of ...Continue Reading

References

Nov 1, 1990·The Journal of Physiology·M Y Wang, N J Dun
Sep 1, 1990·Pharmacology, Biochemistry, and Behavior·M M McCarthyC Beyer
Oct 12, 1973·Science·E V Jensen, E R DeSombre
Apr 11, 1984·Biochimica Et Biophysica Acta·T BräunerR J Strasser
Aug 1, 1995·Progress in Neurobiology·T J Ebner, G Chen
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·G G KuiperJ A Gustafsson
Nov 30, 2000·Neuroreport·T NakamizoS Shimohama
Oct 3, 2001·Physiological Reviews·S NilssonJ A Gustafsson
Jun 12, 2003·Autonomic Neuroscience : Basic & Clinical·Haley L BennettJanet R Keast
May 8, 2004·Endocrinology·Victor V ChabanPaul Micevych
Oct 16, 2004·Endocrinology·Nobuyuki YanagiharaKazumi Tanaka
Nov 6, 2004·The Journal of Biological Chemistry·Eugen BrailoiuNae J Dun
Dec 14, 2004·The Journal of Comparative Neurology·G Cristina BrailoiuNae J Dun
Feb 12, 2005·Science·Chetana M RevankarEric R Prossnitz
Apr 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Phillip E KunklerRichard P Kraig
Apr 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christopher B HuppenbauerKathryn J Jones
Mar 8, 2006·Nature Chemical Biology·Cristian G BologaEric R Prossnitz
Jun 20, 2006·Biochemical and Biophysical Research Communications·Takeshi FunakoshiYoichi Mizukami
Jun 23, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nicoletta BechiLuana Paulesu
Jul 14, 2006·The European Journal of Neuroscience·Tim B HuchoJon D Levine
Aug 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Henry C Evrard
Apr 5, 2007·The Journal of Clinical Endocrinology and Metabolism·María Sonia BaquedanoAlicia Belgorosky
Jul 28, 2007·ACS Chemical Biology·Chetana M RevankarEric R Prossnitz
Aug 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Xiaotang FanJan-Ake Gustafsson

❮ Previous
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Citations

Jan 1, 2010·Journal of Medicinal Chemistry·Chinnasamy RameshJeffrey B Arterburn
May 12, 2009·Nature Chemical Biology·Megan K DennisEric R Prossnitz
Aug 17, 2011·Nature Reviews. Endocrinology·Eric R Prossnitz, Matthias Barton
Aug 24, 2005·Médecine sciences : M/S·Catherine Llorens-Cortès, Alain Beaudet
Jul 3, 2009·American Journal of Physiology. Cell Physiology·Guo-Fen QiaoJohn H Schild
Sep 18, 2012·PloS One·Susannah J SamplePeter Muir
Nov 15, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Adriana Vega OrozcoAna M Rastrilla
Jan 21, 2014·Experimental Neurology·Stella Elkabes, Arnaud B Nicot
Aug 21, 2012·Neurochemical Research·Yan ZhangYu-Qiu Zhang
Oct 30, 2012·Experimental Physiology·G Cristina BrailoiuEugen Brailoiu
Jul 3, 2013·Frontiers in Neuroendocrinology·Åsa Amandusson, Anders Blomqvist
Apr 16, 2013·Biochemical and Biophysical Research Communications·Yanan ShiHaoran Lin
Apr 3, 2013·Molecular and Cellular Endocrinology·Isabel Ruiz-PalmeroMaria-Angeles Arevalo
Aug 4, 2012·The Journal of Pain : Official Journal of the American Pain Society·Elena DeliuEugen Brailoiu
Nov 17, 2009·Brain Research·Keiko TakanamiMitsuhiro Kawata
Sep 8, 2009·Trends in Endocrinology and Metabolism : TEM·Björn Olde, L M Fredrik Leeb-Lundberg
May 16, 2009·Prostaglandins & Other Lipid Mediators·Eric R Prossnitz, Matthias Barton
Dec 15, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y LiB Xue
Mar 27, 2015·Clinical and Experimental Pharmacology & Physiology·Maximilian I Pinkham, Carolyn J Barrett
Jul 21, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Eric R Prossnitz, Helen J Hathaway
Mar 26, 2014·Neurobiology of Disease·D BorsookR Burstein
Nov 27, 2016·Cell Biology International·Xiaonian CaoWen-Liang Zhou
Jun 27, 2017·The Journal of Comparative Neurology·May TranAllan I Basbaum
Aug 27, 2010·Pain·Esther Pogatzki-Zahn
Apr 8, 2014·The Journal of Pharmacology and Experimental Therapeutics·Matthew P RowanWilliam P Clarke
Sep 27, 2019·Journal of Psychopharmacology·Aline Santos MonteDanielle S Macedo
Oct 2, 2019·Current Opinion in Obstetrics & Gynecology·Amy J Voedisch, Nada Hindiyeh

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