Expression of extracellular matrix macromolecules around demineralized freeze-dried bone allografts

Journal of Periodontology
Y XiaoP M Bartold

Abstract

In the present study histochemical techniques were used to identify specific macromolecular components of the extracellular matrix associated with the tissue reaction to demineralized freeze-dried bone allografts (DFDBA) placed under barrier membranes for ridge augmentation. Small biopsies were obtained from tissues underneath the membranes at various times after placement of the DFDBA and processed for routine immunohistochemistry. Sections were stained with antibodies to osteocalcin, collagen type I, collagen type III, decorin, and biglycan. Non-immune serum, irrelevant antibodies, and omission of the primary antibodies served as negative controls. Histologic examination of the biopsies revealed allograft particles surrounded by well-formed fibrous connective tissue with little or no evidence of new bone formation. Vital autogenous bone fragments were present in the peripheral portions of the biopsies and served as positive controls for comparative purposes with the DFDBA particles. Only 7 out of the 20 biopsies studied were found to have any signs of bone formation around the DFDBA particles and in these such bone formation was irregular and inconsistent around the DFDBA particles. Around the periphery of the allograft parti...Continue Reading

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Citations

Nov 28, 2012·Clinics in Sports Medicine·Bart MullerAsheesh Bedi
Oct 9, 2007·Clinics in Sports Medicine·Lawrence V Gulotta, Scott A Rodeo
Nov 3, 2009·Periodontology 2000·Ni-Hung LinP Mark Bartold
Dec 17, 2014·Periodontology 2000·Antonio R SanzAlejandra P Chaparro
Jun 12, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Bo HanMarcel E Nimni
May 23, 2008·Australian Dental Journal·N-H LinP M Bartold
May 13, 1999·Periodontology 2000·W Becker, B E Becker

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