Expression of ezrin radixin moesin proteins in the adult subventricular zone and the rostral migratory stream

Neuroscience
A PerssonH G Kuhn

Abstract

Continuous proliferation occurs in the adult subventricular zone (SVZ) of the lateral ventricles throughout life. In the SVZ, progenitor cells differentiate into neuroblasts, which migrate tangentially along the rostral migratory stream (RMS) to reach their final destination in the olfactory bulb. These progenitor cells mature and integrate into the existing neural network of the olfactory bulb. Long distance migration of neuroblasts in the RMS requires a highly dynamic cytoskeleton with the ability to respond to surrounding stimuli. Radixin is a member of the ERM (Ezrin, Radixin, Moesin) family, which connect the actin cytoskeleton to the extracellular matrix through transmembrane proteins. The membrane-cytoskeleton linker proteins of the ERM family may regulate cellular events with a high demand on cytoskeleton plasticity, such as cell motility. Recently, specific expression of the ERM protein ezrin was shown in the RMS. Radixin however has not been characterized in this region. Here we used immunohistochemistry and confocal microscopy to examine the expression of radixin in the different cell types of the adult subventricular zone niche and in the RMS. Our findings indicate that radixin is strongly expressed in neuroblasts o...Continue Reading

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Citations

Jul 7, 2012·PloS One·Veronica AkleIrina V Zhdanova
Oct 3, 2012·PloS One·Olle R LindbergHans Georg Kuhn
Feb 27, 2013·Glia·Åsa PerssonH Georg Kuhn
Dec 19, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Jun-Jie QinGui-Lin Li
Jun 11, 2014·International Journal of Radiation Biology·Martina BoströmKlas Blomgren
Aug 7, 2019·International Journal of Molecular Sciences·Amin Derouiche, Kathrin D Geiger

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