Expression of Fas receptor on human T lymphocytes under stimulation with Borrelia burgdorferi sensu lato - preliminary results

Advances in Medical Sciences
S GrygorczukM Dąbrowska

Abstract

Apoptosis of activated T lymphocytes is essential to immunoregulation and its abnormalities have been observed in immune system disorders and persistent infections. To asses Borrelia burgdorferi influence on the susceptibility of T lymphocytes to apoptosis, we have measured expression of the Fas death receptor on these cells after incubation with live B. burgdorferi. Peripheral blood mononuclear cells from 23 LD patients (18 with Lyme arthritis, 5 with neuroborreliosis) and 13 healthy controls (C) were incubated for 48 hours with and without live B. burgdorferi spirochetes: B. afzelii, B. garinii or B. burgdorferi sensu stricto. After incubation, Fas expression on CD3+ cells was measured cytometrically with FITC-labeled monoclonal antibody. Median fraction of Fas-expressing T lymphocytes increased under incubation with B. burgdorferi, with more cells expressing Fas after incubation with B. burgdorferi sensu stricto than with B. garinii. There was a tendency for a higher expression of Fas on T lymphocytes from LD patients then from controls, both in unstimulated and B. burgdorferi-stimulated cultures, but it did not reach a level of statistical significance. B. burgdorferi seems to increase Fas expression on CD3+ T lymphocytes, ...Continue Reading

References

Jul 10, 1997·Nature·M IrmlerJ Tschopp
Jul 6, 2000·The EMBO Journal·A O AliprantisA Zychlinsky
Aug 6, 2000·Immunology·E O'FlahertyJ A Kirby
Oct 26, 2000·Nature·P H Krammer
Jan 3, 2001·The Journal of Infectious Diseases·R A KalishA C Steere
Sep 8, 2001·The Journal of Infection·D H Dockrell
Aug 30, 2003·Microbial Pathogenesis·Sandra PerticarariMarina Cinco
Apr 16, 2004·The Journal of Clinical Investigation·Allen C SteereLisa Glickstein
Sep 7, 2004·Annals of Neurology·Andrew R PachnerDiego Cadavid
Mar 17, 2005·Annals of the Rheumatic Diseases·R DinserH Zeidler
Sep 30, 2006·Arthritis and Rheumatism·Allen C Steere, Sheryn M Angelis
Feb 3, 2007·FEMS Immunology and Medical Microbiology·Bettina WilskeUlrike Schulte-Spechtel
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kathryn L JonesAllen C Steere

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Folia haematologica : internationales Magazin für klinische und morphologische Blutforschung
R Sciborski
Frontiers in Bioscience (Landmark Edition)
Ruth FerstlLiam O'Mahony
© 2021 Meta ULC. All rights reserved