Expression of fibroblast growth factor-2 and fibroblast growth factor receptor 1 messenger RNAs in spinal ganglia and sciatic nerve: regulation after peripheral nerve lesion

Neuroscience
C GrotheK Wewetzer

Abstract

In order to determine functional roles of basic fibroblast growth factor (FGF-2) in the peripheral nervous system we have analysed the expression of FGF-2 and FGF receptor 1 (FGFR1) in spinal ganglia and the sciatic nerve under normal conditions and after nerve crush using RNAse protection assay and in situ hybridization. In intact spinal ganglia, both FGF-2 and FGFR1 messenger RNAs are expressed, albeit at different levels. In situ hybridization identifies satellite cells as the source of FGF-2 and sensory neurons as the source of FGFR1 suggesting a paracrine mode of action of FGF-2 on sensory neurons. One day after crush lesion FGF-2 is significantly up-regulated in sensory ganglia L4-L6. Highest levels are found at day 7; control levels are approached after 28 days. FGFR1 messenger RNA, which is strongly expressed in intact spinal ganglia, displays no significant change after lesion. In the intact sciatic nerve, FGFR1 messenger RNA is detected at higher levels than FGF-2 messenger RNA. After injury, both transcripts display a time-dependent up-regulation in both the proximal and distal nerve stump. Schwann cells, as a putative source of the sciatic nerve-derived FGF-2, express both FGF-2 and FGFR1 messenger RNAs in vitro. Th...Continue Reading

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Citations

Mar 23, 2004·Molecular and Cellular Neurosciences·Julia JungnickelClaudia Grothe
May 15, 2002·Life Sciences·Haruhiro SaitoYoshihiro Ishikawa
Jul 7, 2001·Neuroscience·A B McGeachieUNKNOWN Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
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Mar 8, 2007·Annual Review of Neuroscience·Zu-Lin ChenSidney Strickland
Nov 18, 2009·Acta Histochemica Et Cytochemica·Kaori K GunjigakeKazunori Yamaguchi
May 23, 2014·Biochemical Society Transactions·Mallappa K Kolar, Paul J Kingham
Feb 14, 2004·Molecular and Cellular Neurosciences·Julia JungnickelClaudia Grothe
Apr 4, 2009·Journal of Biomedical Materials Research. Part a·Namiko IshikawaChizuka Ide
Apr 6, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Barbara HausottLars Klimaschewski
Nov 10, 2010·Journal of Molecular Neuroscience : MN·Lu-Ting KuoFrancesco Scaravilli
Nov 7, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Yannick TholanceUNKNOWN anti-FGFR3 antibody Study Group
Jan 2, 2015·Cellular and Molecular Life Sciences : CMLS·Benjamin FörthmannPeter Claus
Apr 24, 2018·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Roghayeh MozafariAlexandre Leite Rodrigues Oliveira

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