PMID: 9183688Jun 2, 1997Paper

Expression of fibroblast growth factor-2 in hypoglossal motoneurons is stimulated by peripheral nerve injury

The Journal of Comparative Neurology
K HuberC Grothe

Abstract

We have studied the expression of basic fibroblast growth factor 2 (FGF-2) and FGF receptor 1 (FGFR1) in the hypoglossal motor system during degeneration and regeneration by using an RNase protection assay, in situ hybridization, and Western blot analysis. The FGF-2 transcript was found to be weakly expressed in the hypoglossal motoneurons of the adult rat. Both peripheral transection and crush injury of the hypoglossal nerve resulted in a marked up-regulation of the FGF-2 mRNA in motoneurons of the hypoglossal nucleus (with a peak at 10 and 11 days postlesion) as well as in the proximal and distal nerve stumps. The FGFR1 transcript was strongly expressed by hypoglossal motoneurons of unlesioned rats. Neither axotomy nor crush lesion of the hypoglossal nerve revealed any alteration of the expression level and cellular localization in the hypoglossal nucleus, but they did result in a significant increase of the FGFR1 mRNA level in the proximal and distal nerve stump. Western blot analysis of the hypoglossal nucleus revealed the presence of the 21 kD and 23 kD isoforms and of a weak expression of the 18 kD isoform. Hypoglossal nerve transection resulted in a complete down-regulation of the FGF-2 protein 3 days after lesion. After...Continue Reading

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Citations

Aug 16, 2006·Neuro-degenerative Diseases·Mariana PeharLuis Barbeito
Jan 2, 2015·Cellular and Molecular Life Sciences : CMLS·Benjamin FörthmannPeter Claus
Apr 5, 2002·Journal of Neuroscience Research·Ward PlunetWolfram Tetzlaff
Feb 24, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jeroen van BergeijkPeter Claus
Jan 22, 2013·Cellular and Molecular Life Sciences : CMLS·Benjamin FörthmannPeter Claus

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