Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in human gliomas is associated with unfavorable overall survival

Translational Research : the Journal of Laboratory and Clinical Medicine
Lianshu DingZhen Fu

Abstract

Human glioma is a malignancy that has no effective systemic therapy. Focal adhesion kinase (FAK) is overexpressed in various invasive and metastatic tumor cells. To investigate its prognostic value in human gliomas, which currently is unknown, we examined the expression patterns of FAK and its activated form, phospho-FAK (FAK pY397), and analyzed the correlation between their expression and prognosis in patients with gliomas. Immunohistochemical staining was performed to detect FAK and phospho-FAK expression patterns in the biopsies from 96 patients with primary gliomas. Kaplan-Meier survival and Cox regression analyses were performed to evaluate the prognosis of patients. As a result, the immunohistochemical analysis revealed that FAK and phospho-FAK both were associated significantly with the Karnofsky performance scale (KPS) score and World Health Organization (WHO) grades of patients with gliomas. Especially, the positive expression rates of FAK and phospho-FAK were significantly higher in patients with a higher grade (P = 0.01 and 0.02, respectively) and a lower KPS score (P = 0.006 and 0.008, respectively). The patients with FAK positive expression correlated with a poor prognosis of human gliomas (P = 0.006) as well as p...Continue Reading

References

Oct 9, 1996·International Journal of Cancer. Journal International Du Cancer·L TremblayS Chevalier
Jun 4, 1999·Progress in Biophysics and Molecular Biology·D D SchlaepferD J Sieg
Jun 28, 2000·Cancer·P Kleihues, L H Sobin
Oct 12, 2000·Pediatric Neurosurgery·D ZagzagG D Yancopoulos
Jul 31, 2001·Biochimica Et Biophysica Acta·M D Schaller
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arnab ChakravartiJay S Loeffler
Mar 18, 2003·Journal of Cell Science·J Thomas Parsons
Apr 28, 2004·Current Opinion in Genetics & Development·David D Schlaepfer, Satyajit K Mitra
Jun 29, 2004·Acta Neuropathologica·A GutenbergH C Ludwig
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chien-Tsun KuanDarell D Bigner

❮ Previous
Next ❯

Citations

Feb 9, 2013·The Journal of Biological Chemistry·Michael RittSivaraj Sivaramakrishnan
Jan 29, 2014·Histopathology·Rosa BoschIsolda Casanova
Oct 14, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J C SoriaM Millward
Feb 22, 2018·Glia·Valéria Pereira FerrerRolf Mentlein
Apr 21, 2019·Cells·Tim Hohmann, Faramarz Dehghani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.