Expression of Forkhead-box protein A1, a marker of luminal A type breast cancer, parallels low Oncotype DX 21-gene recurrence scores

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Foluso O AdemuyiwaSunil Badve

Abstract

The Oncotype DX assay is one of the molecular tests that provide predictive and prognostic information to breast cancer patients with estrogen receptor (ER)-positive and node-negative disease. This study evaluates the association of Forkhead-box protein A1 (FOXA1) and GATA-binding protein 3 (GATA3) expressions with Oncotype DX recurrences scores in 77 cases of patients with ER-positive node-negative breast carcinomas diagnosed at Indiana University. The data were correlated with patient age, tumor size, histologic type, Scarff-Bloom-Richardson score, histologic grade, and progesterone receptor status. The median FOXA1 and GATA3 scores were 240 and 200, respectively. The Oncotype DX recurrence scores were low in 57%, intermediate in 30%, and high in 13% of cases. FOXA1 expression correlated negatively with Oncotype DX recurrence scores (P=0.004), and histologic type (P=0.0004). Oncotype DX recurrences score also correlated negatively with progesterone receptor (P=0.035) with 100% of progesterone receptor-negative cases having high or intermediate Oncotype DX scores. FOXA1 and GATA3 expressions correlated positively (P=0.014). The correlation between FOXA1 expression and Oncotype DX recurrence scores remained significant after ad...Continue Reading

References

Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P M RavdinH L Parker
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Dec 20, 2002·The New England Journal of Medicine·Marc J van de VijverRené Bernards
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Feb 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Howard Y ChangMarc J van de Vijver
Aug 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·Josée LaganièreVincent Giguère
Sep 9, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GoldhirschUNKNOWN Panel members
Jan 7, 2006·Molecular Endocrinology·Jason S Carroll, Myles Brown
Mar 4, 2006·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
May 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Soonmyung PaikNorman Wolmark
Aug 11, 2006·The New England Journal of Medicine·Cheng FanCharles M Perou
Dec 26, 2006·Nature Cell Biology·Marie-Liesse Asselin-LabatJane E Visvader
Apr 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sherene LoiChristos Sotiriou
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sunil BadveHarikrishna Nakshatri
Mar 25, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Melina B FlanaganRohit Bhargava
Jun 12, 2008·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·M Ignatiadis, C Sotiriou
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Douglas T RossNorman Wolmark
Feb 11, 2009·Journal of Surgical Oncology·Leonard R HenryPeter W Soballe

❮ Previous
Next ❯

Citations

Nov 30, 2012·Chromosoma·Elisa FioritoAntoni Hurtado
Nov 1, 2011·Breast Cancer Research and Treatment·Petra StuteJ Mark Cline
Apr 3, 2013·European Journal of Pharmacology·Marjolein DroogWilbert Zwart
Jul 7, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N TominagaS Noguchi
Oct 12, 2010·BMC Cancer·Fabrice SircoulombMax Chaffanet
Apr 20, 2011·Breast Cancer Research and Treatment·Rutika J MehtaSunil Badve
Oct 11, 2011·Annals of Surgical Oncology·Yuichi HisamatsuYoshihiko Maehara
Sep 3, 2011·Trends in Genetics : TIG·Luca MagnaniMathieu Lupien
Dec 1, 2015·Archives of Pathology & Laboratory Medicine·Philip E BomeislHannah L Gilmore
May 31, 2012·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Andrew J DalleyCamile S Farah
Jan 15, 2014·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yuichi HisamatsuYoshihiko Maehara
Nov 26, 2011·Bioscience Reports·Gina M Bernardo, Ruth A Keri
May 7, 2013·The Breast : Official Journal of the European Society of Mastology·Helen IngoldsbyGrace Callagy
Apr 28, 2016·The Breast : Official Journal of the European Society of Mastology·Serena Di CosimoValter Torri
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Xiaoyong FuRachel Schiff
Feb 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Qing HuJin-Hai Tang
Mar 16, 2011·Histopathology·Rohit K JainSunil S Badve
Jun 11, 2016·Experimental and Therapeutic Medicine·Keli HeXinghua Long
Dec 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N TominagaS Noguchi
Feb 15, 2020·Analytical Chemistry·Kyung-Cho ChoHui Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

CZI Human Cell Atlas Seed Network

The aim of the Human Cell Atlas (HCA) is to build reference maps of all human cells in order to enhance our understanding of health and disease. The Seed Networks for the HCA project aims to bring together collaborators with different areas of expertise in order to facilitate the development of the HCA. Find the latest research from members of the HCA Seed Networks here.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Sunil BadveHarikrishna Nakshatri
Expert Opinion on Therapeutic Targets
Harikrishna Nakshatri, Sunil Badve
© 2022 Meta ULC. All rights reserved