PMID: 9533775Apr 9, 1998Paper

Expression of four CEA family antigens (CEA, NCA, BGP and CGM2) in normal and cancerous gastric epithelial cells: up-regulation of BGP and CGM2 in carcinomas

International Journal of Cancer. Journal International Du Cancer
T KinugasaY Matsuoka

Abstract

Four human carcinoembryonic antigen (CEA) family members, CEA (CD66e), non-specific cross-reacting antigen (NCA, CD66c), biliary glycoprotein (BGP, CD66a) and CEA gene-family member 2 (CGM2), are expressed in normal mucosal epithelia of the colon. Expression of BGP and CGM2 has recently been demonstrated to be down-regulated in colorectal adenocarcinomas. We have now investigated the expression of the 4 CEA family antigens in gastric adenocarcinoma and carcinoma cell lines in comparison with adjacent normal gastric mucosa. The transcripts of the CEA, NCA and BGP genes evaluated by reverse transcription-polymerase chain reaction were detectable at various levels in all the gastric adenocarcinoma cell lines tested, while CGM2 mRNA was detectable in the cell lines of poorly differentiated but not of well-differentiated carcinomas. The levels of CEA mRNA in normal gastric mucosa were variable but mostly increased in adenocarcinomas. The sparse expression of NCA observed in the normal tissues was markedly up-regulated in the carcinomas. In contrast to previous findings on normal and cancerous colonic tissues, the transcripts of CGM2 were totally undetectable and those of BGP were recognized only marginally, if at all, in normal gast...Continue Reading

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Citations

Feb 5, 2014·Acta Biochimica Et Biophysica Sinica·Yunqiang ZhangMin Yan
Apr 22, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Richard DouardSylvain Loric
May 29, 2007·Oncogene·I Zafir-LavieY Reiter
Oct 29, 2004·The American Journal of Pathology·Alireza EbrahimnejadJens Brümmer
May 9, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Björn Obrink
Nov 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eckart LaackDieter Kurt Hossfeld
Oct 5, 2010·European Journal of Haematology·Karban JosefTrneny Marek
Aug 18, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Wei LiuSylvia L Asa
Nov 28, 2014·Virchows Archiv : an International Journal of Pathology·Ok-Jun LeeHyung Geun Song
Apr 12, 2002·Journal of Clinical Laboratory Analysis·Yukihiko SatohYuji Hinoda
May 26, 2006·Nature Reviews. Immunology·Scott D Gray-Owen, Richard S Blumberg
Mar 13, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ozlem TüreciJuergen Hammer
Jul 29, 2016·Medical Molecular Morphology·Fu-Fang WangCheng-Jun Zhou

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