Expression of fourteen novel obesity-related genes in Zucker diabetic fatty rats.

Cardiovascular Diabetology
Peter M SchmidAndreas Luchner

Abstract

Genome-wide association studies (GWAS) are useful to reveal an association between single nucleotide polymorphisms and different measures of obesity. A multitude of new loci has recently been reported, but the exact function of most of the according genes is not known. The aim of our study was to start elucidating the function of some of these genes. We performed an expression analysis of fourteen genes, namely BDNF, ETV5, FAIM2, FTO, GNPDA2, KCTD15, LYPLAL1, MCR4, MTCH2, NEGR1, NRXN3, TMEM18, SEC16B and TFAP2B, via real-time RT-PCR in adipose tissue of the kidney capsule, the mesenterium and subcutaneum as well as the hypothalamus of obese Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats at an age of 22 weeks. All of our target genes except for SEC16B showed the highest expression in the hypothalamus. This suggests a critical role of these obesity-related genes in the central regulation of energy balance. Interestingly, the expression pattern in the hypothalamus showed no differences between obese ZDF and lean ZL rats. However, LYPLAL1, TFAP2B, SEC16B and FAIM2 were significantly lower expressed in the kidney fat of ZDF than ZL rats. NEGR1 was even lower expressed in subcutaneous and mesenterial fat, while MTCH2 was highe...Continue Reading

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Citations

Jan 15, 2013·Journal of Obesity·Carla Sustek D'Angelo, Celia Priszkulnik Koiffmann
Aug 28, 2013·Nutrition & Diabetes·M GraffK E North
Mar 31, 2015·Physiology & Behavior·Ruth Gutierrez-AguilarYvonne M Ulrich-Lai
Nov 1, 2017·Disease Models & Mechanisms·Rachel A WatsonInês Barroso
Aug 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Rachel LarderAnthony P Coll
Sep 26, 2014·Molecular Biology Reports·Ernesto BurgioLucia Migliore
Aug 3, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Shahbaz KhanKapil Dev
Jul 22, 2018·Nutrition & Diabetes·Venesa SahibdeenZané Lombard
Nov 17, 2020·Frontiers in Genetics·Chang SunEsther Guiu-Jurado

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Methods Mentioned

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EMKA
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