Expression of FoxP2 during zebrafish development and in the adult brain

The International Journal of Developmental Biology
Rina ShahMilan Jamrich

Abstract

Fox (forkhead) genes encode transcription factors that play important roles in the regulation of embryonic patterning as well as in tissue specific gene expression. Mutations in the human FOXP2 gene cause abnormal speech development. Here we report the structure and expression pattern of zebrafish FoxP2. In zebrafish, this gene is first expressed at the 20-somite stage in the presumptive telencephalon. At this stage there is a significant overlap of FoxP2 expression with the expression of the emx homeobox genes. However, in contrast to emx1, FoxP2 is not expressed in the pineal gland or in the pronephric duct. After 72 hours of development, the expression of zebrafish FoxP2 becomes more complex in the brain. The developing optic tectum becomes the major area of FoxP2 expression. In the adult brain, the highest concentrations of the FoxP2 transcript can be observed in the optic tectum. In the cerebellum, only the caudal lobes show high levels of Foxp2 expression. These regions correspond to the vestibulocerebellum of mammals. Several other regions of the brain also show high levels of Foxp2 expression.

Citations

Jun 22, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Constance Scharff, Jana Petri
Oct 28, 2008·BMC Developmental Biology·Joshua L BonkowskyRichard I Dorsky
Jun 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Todd M Preuss
Feb 3, 2016·Journal of Neuroscience Research·Simon PerathonerAlexander D Crawford
Nov 10, 2012·Journal of Chemical Neuroanatomy·Caio MaximinoAnderson Manoel Herculano
Mar 24, 2009·Trends in Genetics : TIG·Simon E Fisher, Constance Scharff
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Aug 4, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Gudrun ViktorinMonte Westerfield
Jan 6, 2015·The Journal of Comparative Neurology·Ezequiel MendozaConstance Scharff
Apr 20, 2018·Brain, Behavior and Evolution·Ian G G PengraAndrew H Bass

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