Expression of Foxp3 in renal tissue of patients with HBV-associated glomerulonephritis and their clinical and pathological characteristics

Experimental and Therapeutic Medicine
Wenge ZhaoChuansheng Liu

Abstract

Our study retrospectively investigated the expression of forkhead/winged helix transcription factor (Foxp3) in renal tissue and clinical features of patients with hepatitis B virus (HBV)-associated glomerulonephritis (HBV-GN). A total of 58 patients with HBV-GN were assigned to group A; 45 serum and renal tissue HBsAg-negative patients with nephritis were group B; 24 serum HBsAg-positive and renal tissue HBsAg-negative patients with slightly increased serum creatinine without nephritis were group C. Clinical manifestations, laboratory indices and renal biopsies were recorded. Expression of Foxp3, CD4 and CD25 in renal tissue was detected by immunohistochemistry. In group A, 74.1% were serum HBeAg-negative, with serum complement C3 level of 0.99±0.27 g/l, and deposition rates of renal complement C3 and C1q in renal tissue of 34.9 and 16.3% respectively; 25.9% were serum HBeAg-positive, with serum complement C3 level of 0.19±0.17 g/l, and deposition rates of renal complement C3 and C1q in renal tissue of 80 and 46.7%, respectively. A significant difference was found in C3 and C1q between HBeAg-negative and HBeAg-positive group (P<0.05). Increased urinary protein and decreased serum albumin were found in patients in group A with m...Continue Reading

References

Mar 4, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·F M LaiK N Lai
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia MontagnoliLuigina Romani
Oct 28, 2003·Nature Immunology·Francesca FallarinoPaolo Puccetti
Feb 28, 2004·American Journal of Nephrology·Rajendra Bhimma, Hoosen Mohamed Coovadia
Oct 16, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roniel CabreraDavid R Nelson
Mar 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeroen N StoopHarry L A Janssen
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mandy J McGeachyStephen M Anderton
Mar 25, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ruth Y LanM Eric Gershwin
Dec 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Itay ShalevGary Levy
May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Jul 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yasushi OnishiShimon Sakaguchi
Aug 23, 2008·Autoimmunity Reviews·Ugo FioccoLeonardo Punzi
Mar 23, 2010·Cell·Dan R Littman, Alexander Y Rudensky
Dec 18, 2013·American Journal of Clinical Pathology·Yongze ZhuangXiaorong Zhong
Dec 31, 2016·Immune Network·Min Kyung Jung, Eui-Cheol Shin

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
electron microscopy
enzyme-linked immunosorbent assay
PCR

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.