Expression of fractalkine receptor CX3CR1 on cochlear macrophages influences survival of hair cells following ototoxic injury.

Journal of the Association for Research in Otolaryngology : JARO
Eisuke SatoKeiko Hirose

Abstract

The role of innate immunity and macrophage recruitment to the inner ear after hair cell injury is a subject where little is known. In this paper, we demonstrate recruitment of monocytes and macrophages to the inner ear after kanamycin. We also examined the effect of fractalkine receptor (CX3CR1) deletion in kanamycin ototoxicity. We observed more functional and structural damage in CX3CR1 null mice compared to wild-type and heterozygous littermates. In order to determine if increased susceptibility to kanamycin resulted from CX3CR1 deletion from cochlear leukocytes, we created bone marrow chimeras by transplanting CX3CR1-null bone marrow into wild-type mice whose native bone marrow was ablated by lethal irradiation. These mice were then treated with kanamycin sulfate. Auditory brainstem responses (ABR), hair cell counts, and numbers of macrophages recruited to the cochlea were recorded in irradiated mice that received either wild-type, CX3CR1 heterozygous, or CX3CR1 knockout bone marrow. A strong correlation was present between numbers of macrophages and hair cell death in recipients transplanted with CX3CR1 null marrow. No correlation between macrophage number and hair cell loss was present in mice transplanted with wild-type ...Continue Reading

References

Jan 1, 1983·Archives of Oto-rhino-laryngology·C S Chen, J C Saunders
Feb 1, 1982·Clinical Otolaryngology and Allied Sciences·G G BrowningR Cortese
Feb 1, 1981·Archives of Otolaryngology·K R HenryD P Frush
Aug 13, 1998·The Journal of Comparative Neurology·S A BhaveM D Coltrera
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·J K HarrisonL Feng
Feb 14, 2003·Hearing Research·Takayuki NakagawaJuichi Ito
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Minh Dang NguyenSerge Rivest
Apr 14, 2004·Acta Oto-laryngologica. Supplementum·Ji Eun LeeJuichi Ito
Jun 29, 2005·The Journal of Comparative Neurology·Keiko HiroseRichard Ransohoff
Jul 16, 2005·Journal of Neuroimmunology·Cristina LimatolaFabrizio Eusebi
Jul 16, 2005·Cell Death and Differentiation·H JiangJ Schacht
Feb 8, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Miguel A CuadrosJulio Navascués
Feb 14, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jens NeumannKlaus Dinkel
May 30, 2006·Nature Neuroscience·Astrid E CardonaRichard M Ransohoff
Nov 1, 2006·Journal of the Association for Research in Otolaryngology : JARO·Nathan B SautterKeiko Hirose
May 15, 2007·Journal of Neuroscience Research·Sabine LadrechMarc Lenoir
Nov 21, 2007·Nature Neuroscience·Bahareh AjamiFabio M V Rossi
Dec 7, 2007·Journal of the Association for Research in Otolaryngology : JARO·Ruth Rebecca TaylorAndrew Forge
Dec 19, 2007·The Journal of Comparative Neurology·Eisuke SatoKeiko Hirose
Dec 25, 2007·Journal of the Association for Research in Otolaryngology : JARO·Elizabeth C OesterleClifford R Hume
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Clotilde LauroCristina Limatola
May 31, 2008·Journal of the Association for Research in Otolaryngology : JARO·Mona TalebLisa L Cunningham
Jun 26, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Adám DénesKrisztina J Kovács
Jun 28, 2008·Journal of the Association for Research in Otolaryngology : JARO·HongSeob SoRaekil Park
Oct 3, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Richard J GoodyearGuy P Richardson
Jan 16, 2009·Cell Stress & Chaperones·Mona TalebLisa L Cunningham

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Citations

Aug 10, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·Dennis R Trune
May 23, 2014·Journal of the Association for Research in Otolaryngology : JARO·Keiko HiroseRichard M Ransohoff
Jun 22, 2014·Journal of the Association for Research in Otolaryngology : JARO·Keiko HiroseAlec N Salt
Dec 29, 2010·Hearing Research·Eric Wersinger, Paul Albert Fuchs
Mar 10, 2011·International Journal of Immunogenetics·T FurutaT Nakashima
May 26, 2015·Cell and Tissue Research·Peter M Vila, Judith E C Lieu
Sep 28, 2014·Journal of the Association for Research in Otolaryngology : JARO·Tiffany G BakerLisa L Cunningham
Sep 8, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hainan LangBradley A Schulte
Feb 23, 2012·Scientific Reports·Saku T SinkkonenStefan Heller
Jul 19, 2017·Journal of the Association for Research in Otolaryngology : JARO·Andrew K WiseRobert K Shepherd
Jan 30, 2018·Frontiers in Molecular Neuroscience·LaShardai N BrownHainan Lang
Jul 12, 2018·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Yukihide MaedaKazunori Nishizaki
Aug 19, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·Mark E Warchol
Oct 8, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wanming ZhaoLan Zhou
Mar 18, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeong-Im WooSung K Moon
Sep 8, 2017·Frontiers in Cellular Neuroscience·Shimon P Francis, Lisa L Cunningham
Jun 21, 2019·International Journal of Molecular Sciences·László KölesTibor Zelles
Jul 30, 2019·Frontiers in Neurology·Wei LiuHelge Rask-Andersen
Jun 13, 2020·Frontiers in Cellular Neuroscience·Erica SadlerLisa L Cunningham
Apr 28, 2017·Frontiers in Cellular Neuroscience·Megan B Wood, Jian Zuo
Sep 6, 2018·Cold Spring Harbor Perspectives in Medicine·Mark E Warchol
Aug 20, 2021·Frontiers in Cellular Neuroscience·Andrew Rigel Stothert, Tejbeer Kaur
Aug 31, 2021·Frontiers in Cell and Developmental Biology·Yuan ZhangRenjie Chai
Sep 15, 2021·Journal of Neuroscience Research·Celia ZhangBo Hua Hu
Sep 21, 2021·Frontiers in Molecular Neuroscience·Ryan J LongeneckerJonathan Kil
Sep 10, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery
Nov 9, 2021·Frontiers in Cellular Neuroscience·Chaorong YuGuoqiang Wan

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