Expression of full-length trkB receptors by reactive astrocytes after chronic CNS injury

Experimental Neurology
R J McKeonT H Large

Abstract

Growth factors, including members of the neurotrophin family, are expressed by neuronal and glial elements following injury to the CNS. In order to assess the capacity for glial cells to respond to neurotrophins at sites of chronic injury, full-length trkB receptors were localized following implantation of a nitrocellulose filter into the cerebral cortex for 30 days. Northern analysis demonstrated that filter implants contained cells expressing transcripts for full-length and truncated trkB receptors, in contrast to the predominant expression of truncated trkB receptors by cultured astrocytes. In situ hybridization and immunohistochemistry using probes to the trkB kinase domain colocalized full-length receptors with GFAP-immunopositive reactive astrocytes adjacent to and within the filter implant. In contrast, OX-42-immunopositive microglia/macrophages were not stained for full-length trkB. These data indicate that reactive astrocytes can express functional trkB receptors following a chronic insult to the cerebral cortex and support the hypothesis that neurotrophins may regulate astrocytic responses to injury.

References

Jul 1, 1992·Journal of Neuroscience Research·L A HuttonJ R Perez-Polo
Jun 26, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W L MaxwellM Berry
Nov 26, 1990·Brain Research·I HozumiW T Norton
Oct 17, 1986·Science·T H LargeL F Reichardt
Jun 1, 1980·The Journal of Cell Biology·K D McCarthy, J de Vellis
Jan 1, 1994·Brain Research Bulletin·J P Schwartz, N Nishiyama
Aug 1, 1995·Journal of Neuroscience Research·G M Gilad, V H Gilad
May 1, 1995·The European Journal of Neuroscience·J D RobackB H Wainer
Mar 14, 1994·Neuroscience Letters·D R FoschiniD P Crockett
May 1, 1994·The European Journal of Neuroscience·J S RudgeN Y Ip
Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·E S AntonW D Matthew
Jan 1, 1993·The European Journal of Neuroscience·N Y IpJ S Rudge
Jan 1, 1993·Brain Research. Molecular Brain Research·S KumarJ de Vellis
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J FrisénD Lindholm
Oct 7, 1996·The Journal of Comparative Neurology·R H FryerL F Kromer
Nov 1, 1996·Brain Research. Molecular Brain Research·B ConnorM Dragunow

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Citations

Oct 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Melissa W VonDranCheryl F Dreyfus
Nov 7, 2006·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Naoki OtaniMichael Brenner
Nov 13, 2010·International Archives of Medicine·Thomas E IchimNeil H Riordan
Sep 1, 2011·Journal of Neuroinflammation·Andrew D GaudetMatt S Ramer
Mar 29, 2008·Behavioural Brain Research·Olivier Raineteau
Jul 14, 2010·Brain Research Bulletin·Elizabeth J Bradbury, Lucy M Carter
Aug 18, 2009·Molecular and Cellular Neurosciences·Laurent WaselleAnne D Zurn
Jul 6, 2007·Experimental Neurology·Larry Benowitz, Yuqin Yin
Nov 10, 2009·Molecular and Cellular Neurosciences·Junko Kimura-KurodaHitoshi Kawano
Sep 6, 2003·Experimental Neurology·Maciej FigielJürgen Engele
Mar 14, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Naoki OtaniKatsuji Shima
Jun 3, 2014·Biological & Pharmaceutical Bulletin·Tomoharu KuboyamaKatsuko Komatsu
Feb 13, 2001·Biochemical and Biophysical Research Communications·D Kryl, P A Barker

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