PMID: 9699534Aug 12, 1998Paper

Expression of fully and under-glycosylated forms of MUC1 mucin in gastric carcinoma

International Journal of Cancer. Journal International Du Cancer
C A ReisM Sobrinho-Simões


The membrane-bound MUC1 mucin is expressed in normal mucosas and the aberrant expression of its under-glycosylated forms has been reported in carcinomas from different sites. Several studies have provided conflicting evidence regarding the relationship between MUC1 expression and outcome in cancer patients. In this study, we investigated the immunohistochemical expression of MUC1 epitopes, using 2 monoclonal antibodies (MAbs): HMFG1, which reacts with the fully glycosylated MUC1, was studied in 73 gastric carcinomas; and SM3, which recognises an under-glycosylated form of MUC1, was studied in 180 cases. HMFG1 stained the antrum foveolar cells and the body glands of normal gastric mucosa, whereas SM3 reactivity was restricted to the perinuclear region of some foveolar cells. Type I intestinal metaplasia exhibited down-regulation of MUC1 expression using both MAbs. Every gastric carcinoma was stained with HMFG1 and 80% with SM3. High levels of expression of HMFG1 were associated with lymphatic invasion, nodal metastatization, and advanced pTNM staging. The expression of SM3 was associated with the histologic (solid) type of carcinoma, expanding growth pattern, wall penetration, lymphatic invasion and age of the patients. Despite ...Continue Reading


Jun 15, 1989·International Journal of Cancer. Journal International Du Cancer·A GirlingJ Taylor-Papadimitriou
Oct 15, 1989·International Journal of Cancer. Journal International Du Cancer·J BurchellT Duhig
Feb 1, 1985·British Journal of Cancer·N BerryJ Taylor-Papadimitriou
Mar 15, 1984·International Journal of Cancer. Journal International Du Cancer·M J WilkinsonR A Sellwood
Jul 15, 1981·International Journal of Cancer. Journal International Du Cancer·J Taylor-PapadimitriouW F Bodmer
Jul 1, 1995·Pathology, Research and Practice·F CarneiroM Sobrinho-Simões
Sep 1, 1995·Journal of Clinical Pathology·M M WalkerD J Evans
Jun 19, 1993·International Journal of Cancer. Journal International Du Cancer·J BaraR Oriol
Apr 1, 1995·Human Pathology·M A McGuckinR G Wright
Mar 23, 1995·Cancer Letters·J HilkensC Patriarca
Dec 1, 1994·Critical Reviews in Oncology/hematology·T LesuffleurF X Real
Aug 1, 1996·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·M I FilipeD M Swallow
Feb 20, 1997·International Journal of Cancer. Journal International Du Cancer·C A ReisM Sobrinho-Simões

❮ Previous
Next ❯


Oct 16, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Joana GomesCelso A Reis
Jul 24, 2004·Critical Reviews in Clinical Laboratory Sciences·Stephan E BaldusFranz-Georg Hanisch
May 9, 2014·International Journal of Molecular Sciences·Norihisa SaekiTeruhiko Yoshida
Mar 14, 2013·Expert Opinion on Medical Diagnostics·Brian C-S LiuDennis J O'Rourke
Mar 20, 2012·Human Immunology·Jeffrey D Konowalchuk, Babita Agrawal
Jun 23, 2009·Human Pathology·Anna Maria ChiaravalliEnrico Solcia
Oct 14, 2008·Biologicals : Journal of the International Association of Biological Standardization·Ye XuGengxi Hu
Jul 29, 2003·Journal of Surgical Oncology·Jaw-Yuan WangShiu-Ru Lin
Jun 15, 2007·Journal of Gastroenterology and Hepatology·Hae-Wan LeeYoung E Park
Dec 17, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Tetsuro OhnoHiroyuki Kuwano
Jan 13, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yih-Huei UenJaw-Yuan Wang
Sep 13, 2005·Gene·Michael Stock, Florian Otto
Aug 21, 2015·Nature Reviews. Cancer·Salomé S Pinho, Celso A Reis
Nov 26, 1999·Biochimica Et Biophysica Acta·J Taylor-PapadimitriouM Dalziel
Jun 25, 2016·Microscopy Research and Technique·Zelal KarakoçMuzaffer Aydın Ketani
Jul 15, 2016·Biomolecules·Henrique O DuarteCelso A Reis
Mar 28, 2013·Chemical Reviews·William R AlleyMilos V Novotny
Jul 30, 2015·PloS One·Joana T de OliveiraFátima Gärtner
Dec 14, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David V GoldDavid M Goldenberg
Jun 4, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A Magalhães, C A Reis
Feb 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·C A ReisM Sobrinho-Simões
Oct 23, 2001·International Journal of Cancer. Journal International Du Cancer·S TsukashitaT Hattori
Sep 21, 2004·World Journal of Gastroenterology : WJG·Hong-Kai ZhangYong-Fen Yi
Jul 30, 2008·Stem Cell Reviews·Prithi Rajan, Roopa Srinivasan
Oct 1, 2008·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Edaise M SilvaFernando Augusto Soares
Oct 22, 2005·Digestive Diseases and Sciences·Su Youn NamIn Sung Song
Feb 16, 2013·British Journal of Cancer·M RashidD M Swallow
Jul 18, 2019·Expert Review of Proteomics·Danielle A Scott, Richard R Drake

❮ Previous
Next ❯

Related Concepts

Related Feeds