Expression of G-CSF receptor on myeloid progenitors

Leukemia & Lymphoma
K Tsuji, Y Ebihara

Abstract

Although granulocyte colony-stimulating factor (G-CSF) has been reported to act on cells of neutrophilic lineage, the expression of receptors for G-CSF (G-CSFR) on human hematopoietic progenitor cells has been unclear. We then analyzed the expression of G-CSFR on human bone marrow and G-CSF mobilized peripheral blood CD34+ cells, and examined the proliferation and differentiation capabilities of sorted CD34+ G-CSFR+ and CD34+ G-CSFR- cells using methylcellulose clonal culture. These results indicate that the expression of G-CSFR on CD34+ cells is restricted to myeloid progenitors, suggesting that the specific activity of G-CSF on myelopoiesis depends on the exclusive expression of its receptor on myeloid progenitors, and that the mobilization of various hematopoietic stem/progenitor cells is not a direct effect of G-CSF in humans.

Citations

Aug 1, 2012·Theoretical Biology & Medical Modelling·Markus ScholzMarkus Loeffler
Jun 29, 2013·International Journal of Pharmaceutics·Ming-Han ChenShigetaka Asano
Aug 2, 2011·Developmental and Comparative Immunology·Barbara A Katzenback, Miodrag Belosevic
Nov 30, 2011·TheScientificWorldJournal·Irene Mavroudi, Helen A Papadaki

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