Expression of GABA in the fetal, postnatal, and adult human retinas: an immunohistochemical study

Visual Neuroscience
Tapas C Nag, Shashi Wadhwa

Abstract

The expression of GABA in the human fetal (12-25 weeks of gestation), postnatal (five-month-old), and adult (35-year-old) retinas was investigated by immunohistochemistry. GABA expression was seen as early as 12 weeks in the undifferentiated cells of the inner neuroblast zone; a few optic nerve fiber layer axons were clearly labeled, suggesting that some of the stained cell bodies were prospective ganglion cells, others could be displaced amacrine cells. From 16-17 to 24-25 weeks, intense labeling was found in the amacrine, displaced amacrine, and some ganglion cells. During this time period, horizontal cells (identified by calbindin immunohistochemistry), undergoing migration (periphery) and differentiation (center), expressed GABA prominently. In the postnatal retina, some horizontal cells were moderately labeled, but very weakly in a few cells, in the adult. The Müller cells developed immunoreactivity first weakly at 12 weeks and then moderately from 16-17 weeks onward. The staining was also evident in the postnatal and adult retinas, showing labeled processes of these glial cells. Virtually no axons in the adult optic nerve and nerve fiber layer were stained; the staining was restricted to a few, large ganglion cells and di...Continue Reading

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Citations

Nov 24, 1999·Brain Research. Developmental Brain Research·T C Nag, S Wadhwa
Nov 28, 2002·Neuroscience·C ChiquetH M Cooper
Mar 28, 2006·Investigative Ophthalmology & Visual Science·Giovanni CasiniNicholas C Brecha
Mar 30, 2004·Glia·Bernd BiedermannAndreas Reichenbach
Sep 1, 2012·American Journal of Ophthalmology·Anita HendricksonCynthia A Toth
Aug 31, 2007·The Journal of Comparative Neurology·Keely M Bumsted-O'BrienDorothea Schulte
Jan 18, 2005·Experimental Eye Research·Michelle Loeliger, Sandra Rees
Jun 6, 2003·The European Journal of Neuroscience·Daniel N Leszkiewicz, Elias Aizenman

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