Expression of galectin-1 in immune cells and glial cells after spinal cord injury

Neuroscience Research
Dai KuriharaToshihide Yamashita

Abstract

Galectin-1, a member of a family of beta-galactoside-binding proteins, is differentially expressed by various tissues and performs a wide range of biological functions. Galectin-1 has been shown to mediate inflammation and to be involved in axonal regeneration in the oxidized form and in axonal degeneration in the reduced form; however, its involvement in injury and the repair processes after spinal cord injury have not been studied. Therefore, we studied galectin-1 expression in injured spinal cords. Immunostaining analysis of galectin-1 in injured spinal cords revealed that galectin-1-expressing cells assembled around the lesion site. Galectin-1 was intensively expressed by neutrophils 1 day, by microglia/macrophages 3 days, and by astrocytes 7 days after spinal cord injury. These results suggest that galectin-1 may be associated with the pathogenesis of spinal cord injury.

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Citations

Feb 15, 2012·Cell and Tissue Research·Bettina LinnartzHarald Neumann
Dec 30, 2014·Molecular and Cellular Neurosciences·Andrew D GaudetPhillip G Popovich
Apr 20, 2011·Neuropathology and Applied Neurobiology·M StancicW Baron
Apr 3, 2012·Biochemical and Biophysical Research Communications·Michelle KilcoyneSiobhán S McMahon
Jul 7, 2020·Frontiers in Pharmacology·Hiba YaseenAmiram Ariel
Oct 21, 2019·Molecular Immunology·Lílian C RodriguesMarcelo Dias-Baruffi

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