Expression of gap junction protein connexin 43 in bovine urinary bladder tumours

Journal of Comparative Pathology
Annunziata CorteggioGiuseppe Borzacchiello

Abstract

The aetiopathogenesis of urinary bladder tumours in cattle involves prolonged ingestion of bracken fern and infection by bovine papillomavirus types 1 or 2 (BPV-1/2). The oncogenic activity of BPV is largely associated with the major oncoprotein E5. Gap junctions are the only communicating junctions found in animal tissues and are composed of proteins known as connexins. Alterations in connexin expression have been associated with oncogenesis. The present study investigated biochemically and immunohistochemically the expression of connexin 43 in samples of normal (n=2), dysplastic (n=3) and neoplastic (n=23) bovine urothelium. The tumours included 10 carcinomas in situ, five papillary urothelial carcinomas and eight invasive urothelial carcinomas. Normal and dysplastic urothelium had membrane expression of connexin 43, but this was reduced in samples of carcinoma in situ. Papillary urothelial carcinomas showed moderate cytoplasmic and membrane labelling, while invasive carcinoma showed loss of connexin 43 expression.

References

Jun 19, 1992·International Journal of Cancer. Journal International Du Cancer·K K WilgenbusO Traub
Oct 1, 1995·Kidney International·T W WhiteD L Paul
Feb 27, 1998·Frontiers in Bioscience : a Journal and Virtual Library·J E Trosko, R J Ruch
Dec 26, 2001·Oncogene·D DiMaio, D Mattoon
Aug 11, 2005·Molecular Cancer·Trond AasenMalcolm B Hodgins
May 16, 2008·Veterinary Research·Giuseppe Borzacchiello, Franco Roperto
Oct 13, 2009·Journal of Comparative Pathology·S RopertoF Roperto

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Citations

Jan 11, 2013·Infectious Agents and Cancer·Annunziata CorteggioGiuseppe Borzacchiello
Aug 10, 2013·Archives of Virology·Rui M Gil da Costa, Rui Medeiros
Oct 30, 2015·World Journal of Urology·Detlev CombergThomas Tschernig
Jan 10, 2012·Journal of Hazardous Materials·R M Gil da CostaC Lopes
Jul 6, 2013·Scientific Reports·Hiromitsu NegoroSylvia O Suadicani
Jan 10, 2012·Transboundary and Emerging Diseases·C C R CarvalhoA C Freitas
Aug 16, 2012·The Veterinary Journal·Maria Angelica SilvaGiuseppe Borzacchiello
Apr 1, 2018·Transboundary and Emerging Diseases·C DaudtC W Canal
May 28, 2019·Cancers·Thomas Tschernig
Jan 12, 2017·Molecular and Cellular Biochemistry·Xiao-Lin AiZhi-Yong Wang

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