Expression of gC1q-R/p33 and its major ligands in human atherosclerotic lesions

Molecular Immunology
Ellinor I PeerschkeB Ghebrehiwet

Abstract

A growing body of evidence supports the hypothesis that atherosclerosis has an inflammatory component, and that immune mechanisms, including complement activation, are likely to be involved. gC1q-R/p33 (gC1q-R) is a multifunctional and multicompartmental cellular protein, which is postulated to play a role in inflammation and thrombosis by interacting with C1q and high molecular weight kininogen (HK). To examine the expression of gC1q-R and its major ligands, C1q and HK, in human atherosclerotic lesions, sections of carotid arteries removed during endarterectomy and coronary arteries obtained at autopsy were stained with specific polyclonal or monoclonal antibodies. Control sections were stained with irrelevant rabbit IgG or isotype matched murine monoclonal antibody (MOPC), respectively. Tissue sections were counterstained with hematoxylin and examined by light microscopy. Specific staining for gC1q-R, C1q, and HK was observed in and around atherosclerotic lesions. In contrast to control antibodies, antibodies directed against gC1q-R reacted with endothelial cells, foam cells, smooth muscle cells, and inflammatory cells present in the intima and media of atherosclerotic lesions. In addition, the necrotic central core of advanc...Continue Reading

Citations

Apr 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Juliana HamzahErkki Ruoslahti
Dec 19, 2006·Molecular Immunology·Wei YinEllinor I Peerschke
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·E I B PeerschkeB Ghebrehiwet
Dec 16, 2010·Journal of Thrombosis and Haemostasis : JTH·W S SpeidlJ Wojta
Jun 18, 2011·Platelets·Saravan Kumar ShanmugavelayudamWei Yin
Mar 19, 2015·Frontiers in Physiology·Johannes PatzeltHarald F Langer
Aug 26, 2009·Respiratory Medicine·Jianqiang ZhangJielin Pu
Mar 24, 2017·The Journal of Experimental Medicine·Michelle E LeBlancWei Li
Oct 12, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Zhu LiuLing-Juan Gao
Jan 15, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lan G CoffmanSuzy V Torti
Apr 6, 2018·Frontiers in Medicine·Monika PathakJonas Emsley
Aug 24, 2016·Cellular and Molecular Bioengineering·Kirstin E BarberDavid A Rubenstein
Oct 27, 2016·Immunological Reviews·Berhane GhebrehiwetEllinor I B Peerschke
Mar 25, 2019·Drug Delivery·Ningning SongJinhua Zhao
Dec 6, 2005·Molecular and Cellular Biochemistry·Joe O MintaJabbal Jones
Aug 9, 2020·Frontiers in Immunology·Claudia DonatMarten Trendelenburg
Nov 21, 2019·Seminars in Immunology·Berhane GhebrehiwetEllinor I B Peerschke
Jun 5, 2007·Immunobiology·Ellinor I B Peerschke, Berhane Ghebrehiwet

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