Expression of GCIP in transgenic mice decreases susceptibility to chemical hepatocarcinogenesis

Oncogene
W MaM Liu

Abstract

Transcription factors with helix-loop-helix (HLH) motif play critical roles in controlling the expression of genes involved in lineage commitment, cell fate determination, proliferation, and tumorigenesis. To examine whether the newly identified HLH protein GCIP/CCNDBP1 modulates cell fate determination and plays a role in hepatocyte growth, proliferation, and hepatocarcinogenesis, we generated transgenic mice with human GCIP gene driven by a liver-specific albumin promoter. We demonstrated that in GCIP transgenic mice, the overall liver growth and regeneration occurred normally after liver injury induced by carbon tetrachloride (CCl4). In the diethylnitrosamine (DEN)-induced mouse hepatocarcinogenesis, we demonstrated that overexpression of GCIP in mouse liver suppressed DEN-induced hepatocarcinogenesis at an early stage of tumor development. The number of hepatic adenomas at 24 weeks was significantly lower or not detected in GCIP transgenic male mice compared to the control mice under the same treatment. Although GCIP has little inhibition on the number of hepatic tumors at later stages (40 weeks), hepatocellular tumors in GCIP transgenic mice are smaller and well-differentiated compared to the poorly differentiated tumors i...Continue Reading

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y ZhuangH Weintraub
Nov 23, 1990·Science·T K BlackwellH Weintraub
Jan 1, 1989·Pharmacology & Therapeutics·R O RecknagelR L Waller
Jan 1, 1987·Toxicologic Pathology·S D Vesselinovitch
Jun 16, 1995·Cell·M P PeppelenboschJ L Bos
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·A F Voronova, F Lee
Jun 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S Y HwangB B Knowles
Jan 9, 1999·The Journal of Biological Chemistry·X F Zhao, P D Aplan
Dec 28, 1999·Molecular and Cellular Biology·M E Massari, C Murre
Dec 30, 1999·Nature Genetics·J JensenO D Madsen
Aug 1, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S TeraiS S Thorgeirsson
Aug 10, 2000·Immunological Reviews·B L KeeC Murre
Oct 24, 2000·Oncogene·E A ConnerS S Thorgeirsson
Mar 27, 2001·Japanese Journal of Cancer Research : Gann·T NakataniA Ito
Jan 25, 2002·Journal of Cellular Physiology·Yoshifumi Yokota, Seiichi Mori
Feb 13, 2002·Oncogene·Z Zebedee, E Hara
Oct 24, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanna M Ledda-ColumbanoAmedeo Columbano
Jul 31, 2003·Trends in Cell Biology·Marianna B Ruzinova, Robert Benezra

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Citations

Jan 21, 2009·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Azusa SetoOsamu Nureki
May 24, 2015·Journal of Biochemistry·Mitsuyoshi MotizukiKeiji Miyazawa
Jan 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Eva Sonnenberg-RiethmacherDieter Riethmacher
Nov 30, 2006·Journal of Cellular Biochemistry·Wenbin MaMingyao Liu
Aug 24, 2018·Cancer Investigation·Zofia Hélias-RodzewiczJean-François Emile
Jan 8, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ruei-Yue LiangShow-Mei Chuang
Jun 25, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Shao-Wen ZhuWei Liu

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