Expression of GDNF and its receptors in the periodontal mechanoreceptor

Neuroscience Letters
Megumi AitaT Maeda

Abstract

Our previous studies have revealed the involvement of signaling pathways of BDNF and NT-4/5 via TrkB in the development, regeneration, survival and maintenance of the Ruffini endings, primary mechanoreceptors in the periodontal ligament. However, the involvement of other neurotrophins remains unclear. The present study examined the expression of GDNF, GFRalpha1, and RET in the incisor periodontal ligament and trigeminal ganglion of young rats by RT-PCR and immunocytochemistry. All these mRNAs were detected in both tissues by RT-PCR. These immunoreactions were found in the terminal Schwann cells associated with the periodontal Ruffini endings, as confirmed by histochemistry for non-specific cholinesterase activity. Their axonal branches showed GFRalpha1- and RET-immunoreactions but lacked GDNF-immunoreactivity. In the trigeminal ganglion, about 30% of the neurons were immunoreactive to GFRalpha1 and RET. Averages of cross-sectional areas of their positive neurons demonstrated that they could mainly be categorized as medium-sized neurons. GDNF-immunoreaction was restricted to the satellite cells and not in trigeminal ganglion neurons. These findings indicate that GDNF mediates trophic effects on the survival and target innervatio...Continue Reading

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Citations

Mar 19, 2014·European Journal of Medical Genetics·Yeliz GuvenPiranit Nik Kantaputra
Dec 21, 2006·Neuroscience Letters·Yasushi IgarashiTakeyasu Maeda
Jun 17, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Megumi OhishiTakeyasu Maeda
Jun 8, 2007·Brain Research·Batheegama Gammacharige Tharanga Lakmali NandasenaTakeyasu Maeda
Jan 25, 2007·The Journal of Comparative Neurology·Shahiqul JabbarTakeyasu Maeda

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