Expression of genes participating in regulation of fatty acid and glucose utilization and energy metabolism in developing rat hearts

American Journal of Physiology. Heart and Circulatory Physiology
Eduard N LavrentyevG A Cook

Abstract

The heart is a unique organ that can use several fuels for energy production. During development, the heart undergoes changes in fuel supply, and it must be able to respond to these changes. We have examined changes in the expression of several genes that regulate fuel transport and metabolism in rat hearts during early development. At birth, there was increased expression of fatty acid transporters and enzymes of fatty acid metabolism that allow fatty acids to become the major source of energy for cardiac muscle during the first 2 wk of life. At the same time, expression of genes that control glucose transport and oxidation was downregulated. After 2 wk, expression of genes for glucose uptake and oxidation was increased, and expression of genes for fatty acid uptake and utilization was decreased. Expression of carnitine palmitoyltransferase I (CPT I) isoforms during development was different from published data obtained from rabbit hearts. CPT Ialpha and Ibeta isoforms were both highly expressed in hearts before birth, and both increased further at birth. Only after the second week did CPT Ialpha expression decrease appreciably below the level of CPT Ibeta expression. These results represent another example of different expres...Continue Reading

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Citations

Aug 2, 2011·Cardiovascular Research·Tineke van de WeijerPatrick Schrauwen
Jul 27, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·M PaczkowskiR L Krisher
Dec 16, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Andreas Stahl

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