Expression of glial antigens C1 and M1 in developing and adult neurologically mutant mice

Journal of Supramolecular Structure and Cellular Biochemistry
I Sommer, M Schachner

Abstract

The distribution of two glial antigens (C1 and M1) has been studied by indirect immunofluorescence during postnatal development of the cerebella of normal and neurologically mutant mice (weaver, staggerer, reeler, Purkinje cell degeneration, and wobbler). During the first postnatal week of normal development, C1 antigen is expressed in ependyma. Bergmann glial fibers (BG), and astrocytes of the internal granular layer and white matter. After day 10, C1 antigen is restricted to BG and ependymal cells. During the second and third week. BG undergo a transient loss of C1 antigen that starts in medioventral areas and spreads in a gradient dorsally and laterally. In reeler, weaver, and staggerer, C1 antigen expression is normal during the first postnatal week, and subsides in BG in a similar spatial gradient as described for the normal littermates. However, the loss of C1 antigen in BG occurs earlier (first in reeler, then in weaver, and last in staggerer) and is not reversible as it is in normal mice. In Purkinje cell degeneration, C1 antigen expression is diminished in BG after the onset of behavioral abnormalities. Wobbler is normal with respect to C1 antigen expression at adult ages. M1 antigen is detectable in white matter astro...Continue Reading

References

Nov 2, 1977·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J MarianiC Sotelo
Jan 1, 1978·Brain Research Bulletin·C GoridisM Schachner
Jan 1, 1978·The Journal of Comparative Neurology·S C Landis, R J Mullen
Jan 1, 1978·Annual Review of Neuroscience·V S Caviness, P Rakic
Jun 15, 1978·The Journal of Comparative Neurology·D M Landis, R L Sidman
Jan 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R J MullenR L Sidman
Jan 1, 1975·Journal of Neuropathology and Experimental Neurology·J M Andrews
Jun 15, 1975·The Journal of Comparative Neurology·R P Skoff
Dec 11, 1975·Nature·R J Mullen, M LaVail
Mar 1, 1971·Journal of the Neurological Sciences·W F Blakemore
Jan 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·P Rakic, R L Sidman
May 1, 1972·The Journal of Comparative Neurology·P Rakic
Jan 15, 1973·The Journal of Comparative Neurology·V S Caviness, R L Sidman
Nov 15, 1973·The Journal of Comparative Neurology·P Rakic, R L Sidman
Mar 29, 1974·Brain Research·G D DasJ P McAllister
May 7, 1971·Brain Research·L F EngB Gerstl
Dec 1, 1968·Journal of Neurology, Neurosurgery, and Psychiatry·L W Duchen, S J Strich
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·C Lagenaur, M Schachner
Oct 1, 1980·Developmental Biology·C LagenaurM Schachner
Feb 1, 1980·Experimental Neurology·T MurakamiW G Bradley

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Citations

Jul 1, 1982·Journal of Neurochemistry·M Schachner

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