Expression of glucocorticoid receptors in the hippocampal region of the rat brain during postnatal development

Journal of Chemical Neuroanatomy
Anastasia GaleevaMarkku Pelto-Huikko

Abstract

Circulating glucocorticoids, of which their concentration is largely under the control of the hypothalamic-pituitary adrenal (HPA) axis, acting through the glucocorticoid receptors (GR) regulate a large variety of pivotal functions of the organism such as growth, development, immune- and stress-response. The main mechanism of regulation of the HPA axis activity is via negative feedback at all levels of the HPA axis itself as well as at the extra-hypothalamic level, a central part of which is the hippocampus. During neonatal development, the HPA axis of rats undergoes a period of hyporesponsiveness (SHRP)-when most stress stimuli fail to induce stress-response. Here, we describe the pattern of GR proteins expression in the hippocampal area of the rat brain during postnatal development and in adulthood. We demonstrated that the GR protein, of which its expression level is gradually enhanced in the hippocampus during postnatal life, exists in three different molecular sized forms. A larger molecular form was expressed at rather high levels at all studied time periods. A second smaller variant of GR was transiently expressed during the first one and a half weeks that corresponds with SHRP and then appeared again only in the adultho...Continue Reading

References

Aug 18, 1978·Anatomy and Embryology·A R SchlessingerL W Swanson
Jul 16, 1991·Brain Research. Developmental Brain Research·J A van EekelenE R de Kloet
Dec 1, 1989·The Journal of Clinical Investigation·J E KalinyakA R Hoffman
Jan 1, 1987·Annals of the New York Academy of Sciences·M F DallmanJ Shinsako
Apr 1, 1989·Experimental Neurology·H HashimotoM C Bohn
Aug 1, 1986·Endocrine Reviews·R M SapolskyB S McEwen
Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·D GiulianL A Pohorecky
Dec 15, 1980·The Journal of Comparative Neurology·S A Bayer
Oct 1, 1994·Molecular and Cellular Neurosciences·S J YiT Z Baram
Apr 19, 1996·The Journal of Biological Chemistry·R H OakleyJ A Cidlowski
Jun 1, 1996·Journal of Neuroendocrinology·M BrönnegårdC Marcus
Feb 1, 1997·Trends in Neurosciences·J P Herman, W E Cullinan
Jan 1, 1997·The Journal of Steroid Biochemistry and Molecular Biology·C M BambergerH M Schulte
Oct 23, 1997·The Journal of Biological Chemistry·C OttoG Schütz
Apr 29, 1998·Annual Review of Physiology·K L King, J A Cidlowski
Jun 18, 1998·Annals of the New York Academy of Sciences·D Y LeungG P Chrousos
Dec 22, 1999·Biological Psychiatry·E Gould, P Tanapat
Mar 10, 2000·Pediatric Research·S G Matthews
Dec 12, 2001·Molecular and Cellular Endocrinology·J R Seckl
May 7, 2002·Journal of Clinical and Experimental Neuropsychology·Amy L Alderson, Thomas A Novack
Jun 22, 2002·Pharmacology, Biochemistry, and Behavior·A CatalaniL Angelucci
Jul 22, 2004·Annals of the New York Academy of Sciences·Naima Ismaili, Michael J Garabedian
Jul 22, 2004·Annals of the New York Academy of Sciences·Nick Z Lu, John A Cidlowski

❮ Previous
Next ❯

Citations

Jan 16, 2009·Bulletin of Experimental Biology and Medicine·N E OrdyanS G Pivina
Jun 29, 2010·The Tohoku Journal of Experimental Medicine·Akiko KojoToshiharu Yamamoto
Dec 4, 2012·Frontiers in Neuroendocrinology·Fuxia Xiong, Lubo Zhang
Jul 16, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Lin Xiao, Yizhang Chen
Mar 7, 2008·European Journal of Pharmacology·Roel H Derijk, E Ron de Kloet
Aug 31, 2011·Neural Plasticity·Cristiano André KöhlerJuliana Sartori Bonini
May 21, 2013·Journal of Neuroscience Research·Yan Dong ZhaoHuai Zhen Ruan
Jan 24, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Vesna TesicSelma Kanazir
Apr 22, 2008·European Journal of Pharmacology·Roel H DerijkFrans G Zitman
Aug 3, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Christine HeberdenMonique Lavialle
Oct 17, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Daniela OgiasPatrícia Gama

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Related Papers

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Mathias V SchmidtMelly S Oitzl
Brain Research. Developmental Brain Research
Mathias V SchmidtE Ronald de Kloet
© 2021 Meta ULC. All rights reserved