Expression of glycine receptor alpha 3 in the rat trigeminal neurons and central boutons in the brainstem

Brain Structure & Function
Jin Young BaeYong Chul Bae

Abstract

Increasing evidence shows that the homomeric glycine receptor is expressed in axon terminals and is involved in the presynaptic modulation of transmitter release. However, little is known about the expression of the glycine receptor, implicated in the presynaptic modulation of sensory transmission in the primary somatosensory neurons and their central boutons. To address this, we investigated the expression of glycine receptor subunit alpha 3 (GlyRα3) in the neurons in the trigeminal ganglion and axon terminals in the 1st relay nucleus of the brainstem by light- and electron-microscopic immunohistochemistry. Trigeminal primary sensory neurons were GlyRα3-immunopositive/gephyrin-immunonegative (indicating homomeric GlyR), whereas GlyRα3/gephyrin immunoreactivity (indicating heteromeric GlyR) was observed in dendrites. GlyRα3 immunoreactivity was also found in the central boutons of primary afferents but far from the presynaptic site and in dendrites at subsynaptic sites. Boutons expressing GlyRα3 contained small round vesicles, formed asymmetric synapses with dendrites and were immunoreactive for glutamate. These findings suggest that trigeminal primary afferent boutons receive presynaptic modulation via homomeric, extrasynaptic...Continue Reading

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Citations

Feb 21, 2018·Brain Structure & Function·Jin Young BaeYong Chul Bae
Jul 11, 2018·Cephalalgia : an International Journal of Headache·Karl Messlinger, Andrew F Russo
Aug 10, 2017·Cellular and Molecular Life Sciences : CMLS·Hanns Ulrich ZeilhoferGonzalo E Yévenes
Feb 24, 2020·Journal of Neural Transmission·Karl MesslingerAndrew F Russo
Mar 18, 2020·Scientific Reports·Gustavo Moraga-CidGonzalo E Yévenes
Nov 9, 2021·Frontiers in Molecular Neuroscience·Loreto S San MartinLuis G Aguayo

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