PMID: 9442830Jan 27, 1998Paper

Expression of glycoconjugates in normal and Sjögren's syndrome labial glands

Acta Oto-laryngologica
J SidagisM Ohyama

Abstract

Glyconjugate expression in formalin-fixed, paraffin-embedded Sjögren's syndrome labial glands (nine cases) was compared with that in normal glands (12 samples) using a wide panel of lectins. Mucous cells expressed mainly mucous-type glycoproteins including sialyl, fucosyl, galactosyl and galactosaminosyl residues, and some N-linked glycoconjugates. Demilunar cells expressed mainly alpha D-mannose, GlcNAc and Gal beta 1.3-GalNAc. Duct cells and cellular glycocalyx expressed O-linked and N-linked residues. Sjögren's syndrome samples showed a statistically significant increase in the expression of GlcNAc. A significantly decreased expression of Gal beta 1,3-GalNAc and alpha D-mannose, residues not usually present in mucous cells, was found (p < 0.05). This suggests that anatomic rather than functional alterations determine mucous cell impairment and the symptoms in Sjögren's syndrome.

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Citations

Jan 4, 2008·Investigative Ophthalmology & Visual Science·Mika SumiyoshiPablo Argüeso
Jul 22, 1999·Archives of Oral Biology·A R HandR B Field

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