Expression of GPR177 (Wntless/Evi/Sprinter), a highly conserved Wnt-transport protein, in rat tissues, zebrafish embryos, and cultured human cells.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Jay JinR Levenson

Abstract

GPR177 is an evolutionarily conserved transmembrane protein necessary for Wnt protein secretion. Little is currently known, however, regarding expression of GPR177, especially in vertebrate species. We have developed an antiserum against GPR177, and used it to examine expression of GPR177 in human tissue culture cells, adult mouse, and rat tissues, as well as developing zebrafish embryos. In rodents, GPR177 is expressed in virtually all tissue types and brain regions examined. In zebrafish, GPR177 polypeptides are expressed throughout embryogenesis, and are detectable as early as 1 hr post-fertilization. In situ hybridization analysis reveals that gpr177 mRNA expression is prominent in embryonic zebrafish brain and ear. Structural studies suggest that GPR177 is modified by N-linked sugars, and that the protein contains an even number of transmembrane segments. The relatively ubiquitous expression of GPR177 suggests that this protein may serve to regulate Wnt secretion in a variety of embryonic and adult tissue types.

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Citations

Dec 8, 2011·EMBO Molecular Medicine·Iris AugustinMichael Boutros
Nov 15, 2011·Gene·David G MonroeJennifer J Westendorf
Mar 13, 2015·Journal of Bone and Mineral Metabolism·Péter HorváthIstván Takács
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Jul 10, 2019·BMC Molecular and Cell Biology·Jessica PetkoRobert Levenson
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Nov 12, 2017·Digestive Diseases and Sciences·Chao ZhouJiandong Wang
Mar 21, 2018·BMB Reports·Jaesung SeoJae-Ho Cheong

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