PMID: 7520716Jan 1, 1994Paper

Expression of granulocyte colony-stimulating factor and its receptor at the fetomaternal interface in murine and human pregnancy

Growth Factors
S SaitoS Nagata

Abstract

Granulocyte colony-stimulating factor (G-CSF) is a cytokine which regulates proliferation and differentiation of neutrophilic granulocytes, and its receptor (G-CSF-R) is a member of the hemopoietic growth factor receptor family. We studied the expression of G-CSF and G-CSF-R at the fetomaternal interface in murine and human pregnancy. Immunohistochemical analysis and in situ hybridization indicated that both G-CSF and G-CSF-R are expressed in mouse spongiotrophoblasts and placental labyrinths, and human placental cytotrophoblasts and syncytiotrophoblasts. They were also detected in mouse decidual basalis cells and endometrial epithelial cells, and human decidual stromal cells and endometrial gland cells. These results suggest that G-CSF plays a role in decidual and placental functions by autocrine and paracrine mechanisms.

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Citations

Aug 5, 2000·Journal of Reproductive Immunology·S Saito
Oct 16, 2001·Journal of Reproductive Immunology·S Saito
Apr 9, 1999·Early Human Development·W B SlaytonR D Christensen
Oct 7, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jason A GerstingDarlene A Calhoun
Nov 1, 1996·American Journal of Reproductive Immunology : AJRI·D M SvinarichB Gonik
Mar 3, 2001·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·T TanakaS Ogita
Aug 28, 1999·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·K MatsubaraM Ito
Feb 6, 2016·American Journal of Reproductive Immunology : AJRI·Arsène MekinianMarie Bornes
Nov 27, 2015·Biological Reviews of the Cambridge Philosophical Society·Eline WydoogheAnn Van Soom
Oct 11, 2005·American Journal of Reproductive Immunology : AJRI·Silvana LitwinSilvia Miranda
Apr 17, 2008·The Journal of Obstetrics and Gynaecology Research·Masashi KikkawaMitsuaki Suzuki
Apr 4, 2009·American Journal of Reproductive Immunology : AJRI·Maria MatteoArcangelo Liso
Feb 28, 2015·Journal of Reproductive Immunology·Mona RahmatiNathalie Ledee
Feb 13, 1997·Biochemical and Biophysical Research Communications·S SaitoH Morikawa
Mar 20, 1999·Biology of Reproduction·D Fairchild Benyo, K P Conrad
Mar 17, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Ashraf AleyasinMahdi Sheikh
Sep 15, 2000·Clinics in Perinatology·D A Calhoun, R D Christensen

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