Expression of GRIM-19 in adenomyosis and its possible role in pathogenesis

Fertility and Sterility
Jing WangLan Chao

Abstract

To study the expression of the gene associated with retinoid-interferon (IFN)-induced mortality 19 (GRIM-19) in the endometrial tissue of patients with adenomyosis and to describe the possible pathogenic mechanisms of this phenomenon. Experimental study using human samples and cell lines. University-affiliated hospital. Ectopic and eutopic endometrial tissues were obtained from 30 patients with adenomyosis, whereas normal endometrial specimens were obtained from 10 control patients without adenomyosis. Patients with rapid pathology report-confirmed adenomyosis were recruited, and eutopic and ectopic endometrial tissue samples were collected from patients who had undergone hysterectomies by either the transabdominal or laparoscopic method at Qilu Hospital. Normal endometrial tissue was collected from a group of control patients without adenomyosis. Immunohistochemistry (IHC) was performed to evaluate the expression of GRIM-19, phospho-signal transducer and activator of transcription 3 (Y705) (Y705) (pSTAT3(Y705)), and vascular endothelial growth factor (VEGF) in endometrial tissue samples. The protein levels of GRIM-19, pSTAT3(Y705), STAT3, and VEGF were detected by Western blot. Apoptosis in endometrial specimens was assayed by...Continue Reading

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Citations

Apr 29, 2020·Zygote : the Biology of Gametes and Early Embryos·M JamilR Cadi
Dec 10, 2019·Journal of Cellular and Molecular Medicine·Xuan CheXinmei Zhang
Sep 11, 2019·Human Reproduction Update·Marissa J HarmsenJudith A F Huirne
Oct 9, 2020·Seminars in Reproductive Medicine·Junyu ZhaiLinda C Giudice
Oct 23, 2020·Reproductive Sciences·Christina Anna StratopoulouMarie-Madeleine Dolmans
Jan 10, 2021·Reproductive Biology and Endocrinology : RB&E·Song GuoYijuan Sun

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