PMID: 15385778Sep 24, 2004Paper

Expression of growth factors in canine flexor tendon after laceration in vivo

Annals of Plastic Surgery
Tetsu TsuboneKai-Nan An

Abstract

Growth factors, transforming growth factor beta (TGF-beta), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), insulin-like growth factor (IGF), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF), are critical components of the cutaneous wound healing process. Little is known, however, about the expression of these growth factors in normal flexor tendon healing. In this study, we wished to examine which of these growth factors are present at 10 days following tendon injury in a canine flexor tendon repair model. Using immunohistochemical analysis, we found positive staining for all growth factors in both timing groups. TGF-beta was detected around the repair site and proximal to it. PDGF-AA, PDGF-BB and VEGF appeared in the whole tendon section following repair. EGF, IGF and bFGF were not seen in tenocytes but were present in inflammatory cells surrounding the repair site. These findings provide evidence that TGF-beta, EGF, PDGF-AA, PDGF-BB, IGF, bFGF and VEGF are all expressed at 10 days after tendon injury but by different cell types and in different locations. The time course of growth factor expression is an important element in wound healing, and a better understanding o...Continue Reading

References

Jul 1, 1991·The Journal of Hand Surgery·R H GelbermanW Akeson
Jul 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S O AbrahamssonL S Lohmander
Jul 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S O AbrahamssonL S Lohmander
Jan 1, 1986·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R H GelbermanD Amiel
Jul 1, 1995·The Journal of Hand Surgery·F J DuffyC A Hergrueter
Jul 1, 1993·American Journal of Surgery·N T Bennett, G S Schultz
Jun 1, 1993·American Journal of Surgery·N T Bennett, G S Schultz
Jan 1, 1997·The International Journal of Biochemistry & Cell Biology·S O'Kane, M W Ferguson
Mar 1, 1997·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S O Abrahamsson
Sep 2, 1999·The New England Journal of Medicine·A J Singer, R A Clark
May 5, 2000·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·R KurodaK Mizuno
May 18, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M BidderM I Boyer
Oct 29, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M TsuzakiA J Banes
Sep 20, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M I BoyerS R Cai
Jul 20, 2002·The Journal of Hand Surgery·Matthew B KleinJames Chang
Jan 1, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michael A Conlon, Frank M Tomas
Mar 1, 1941·Annals of Surgery·M L Mason, H S Allen

❮ Previous
Next ❯

Citations

Feb 14, 2012·Cell and Tissue Research·Karen RuschkePetra Knaus
Dec 8, 2011·Tissue Engineering. Part B, Reviews·Christopher K HeeJeffrey O Hollinger
Aug 9, 2011·Sports Medicine and Arthroscopy Review·Francesco OlivaNicola Maffulli
Dec 2, 2014·The Orthopedic Clinics of North America·Kevin F LutskyJonas L Matzon
Jan 14, 2016·Veterinary Research Communications·Chiara GomieroJan H Spaas
Aug 20, 2010·Expert Opinion on Biological Therapy·Isabel AndiaNicola Maffulli
Sep 22, 2006·Connective Tissue Research·Jens L OlesenAllan Flyvbjerg
Jun 23, 2012·The Journal of Hand Surgery·Daisuke SatoToshihiko Ogino
Mar 29, 2011·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Dimitris N LyrasGeorge Agrogiannis
Feb 12, 2008·The Journal of Hand Surgery·Roshan JamesA Bobby Chhabra
Oct 18, 2007·Journal of Shoulder and Elbow Surgery·Carola C Würgler-HauriLouis J Soslowsky
May 20, 2015·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Claudio RafolsJulio Rosales
May 11, 2010·Orthopaedics & Traumatology, Surgery & Research : OTSR·D N LyrasM Tryfonidis
Jul 28, 2016·Archives of Orthopaedic and Trauma Surgery·Jorge Díaz HerediaR Ruiz Díaz
Oct 29, 2013·The Journal of Hand Surgery, European Volume·O A BranfordK J Rolfe
Aug 31, 2010·The American Journal of Sports Medicine·Jianying Zhang, James H-C Wang
Jun 9, 2017·Journal of Tissue Engineering and Regenerative Medicine·A I GonçalvesM E Gomes
May 11, 2011·The American Journal of Sports Medicine·Christopher K HeeBrandon G Santoni
Apr 22, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Catherine K KuoRocky S Tuan
May 1, 2008·Clinical Orthopaedics and Related Research·Brett M Andres, George A C Murrell
Apr 13, 2017·The Open Orthopaedics Journal·Dimitrios GiotisNikolaos K Paschos
Sep 28, 2005·Birth Defects Research. Part C, Embryo Today : Reviews·Samuel Tozer, Delphine Duprez
Feb 16, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Leena H NakamaDavid M Rempel
Feb 22, 2007·Plastic and Reconstructive Surgery·Eduardo AnituaIsabel Andia
Oct 1, 2019·Plastic and Reconstructive Surgery·Ashley L TitanMichael T Longaker
Mar 26, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Philipp R A SchneiderMehdi Shakibaei
Dec 25, 2015·Current Medical Research and Opinion·G Lozano-OrtegaJ Mukherjee
Aug 17, 2021·Frontiers in Medicine·Zhi Jie LiYou Lang Zhou

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