Expression of growth factors in the gingival crevice fluid of patients with phenytoin-induced gingival enlargement

Archives of Oral Biology
L KuruU Noyan

Abstract

The mechanism underlying phenytoin (PHT)-induced gingival enlargement (GE) is not yet known. The aim of the present study was to investigate transforming growth factor-beta1 (TGF-beta1), platelet-derived growth factor-BB (PDGF-BB) and basic fibroblast growth factor (bFGF) profiles in the gingival crevice fluid (GCF) of patients with PHT-induced GE and to compare the results with healthy controls. Five PHT-treated patients and five healthy subjects with normal periodontal tissue were included in this study. GCF samples were collected from (i) enlarged gingival sites in patients receiving PHT (GE+); (ii) non-enlarged gingival sites in the same patients (GE-); (iii) normal gingival sites of healthy subjects (control). The levels of TGF-beta1, PDGF-BB and bFGF in the GCF samples were analysed by ELISA. The results showed that the total amounts of TGF-beta1 and PDGF-BB in the GE+ group were higher than in the GE- group and significantly higher than in the control group (P < 0.05). However, no significant differences were found between the groups when the concentrations of these growth factors were compared. bFGF levels were not compared as this growth factor could be detected in only 33, 41 and 44% of the GE+, GE- and control GCF sa...Continue Reading

References

May 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·R S BrownW K Bottomley
Jan 1, 1991·Annual Review of Medicine·T F DeuelA F Pierce
Jan 1, 1988·Journal of Periodontal Research·G S GriffithsJ M Wilton
Jul 18, 1986·Cell·R RossD F Bowen-Pope
Jul 1, 1985·Journal of Clinical Periodontology·R A SeymourD N Turnbull
Dec 1, 1972·Oral Surgery, Oral Medicine, and Oral Pathology·A P Angelopoulos, P W Goaz
Feb 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A PagliariniR Evangelisti
Feb 1, 1994·International Journal of Radiation Oncology, Biology, Physics·J N FinkelsteinP Rubin
Jan 1, 1993·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·C P KiritsyS E Lynch
Feb 26, 1998·Journal of Clinical Periodontology·T Sasaki, E Maita
Apr 16, 1998·Journal of Dental Research·L KuruI Olsen
Oct 1, 1993·Periodontology 2000·A F Hefti
Feb 28, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Maria Trojanowska
Mar 19, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Axel M GressnerSteven Dooley
Mar 27, 2003·Periodontology 2000·Gareth S Griffiths
Apr 25, 2003·Journal of Periodontology·Maria Leticia B PinheiroRicardo A Luz
Feb 11, 2004·Chest·Ulrike Bartram, Christian P Speer

❮ Previous
Next ❯

Citations

Jun 25, 2009·Pharmacological Reviews·Hannu JärveläinenRisto Penttinen
Jun 10, 2016·Journal of Clinical Periodontology·Sabrina Rebollo ZaniRicardo Palmier Teles
Nov 30, 2004·Dental Clinics of North America·Tara EsmeiliJoel Epstein
Apr 11, 2015·Journal of Dental Research·W H YangM Y P Kuo
Feb 26, 2016·Journal of Dental Research·W H YangM Y P Kuo
Apr 24, 2013·Journal of Dental Research·W-H YangJ Z-C Chang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.