PMID: 11913688Mar 27, 2002Paper

Expression of heat shock protein 70 in the cochlea in experimental autoimmune inner ear disease

The Annals of Otology, Rhinology, and Laryngology
Shu-Sheng Gong, Z Yan

Abstract

To explore whether the immune response of the inner ear could induce heat shock protein 70 (hsp70) in the guinea pig cochlea, we established a model of autoimmune inner ear disease (AIED) by systemically immunizing guinea pigs with homologous crude inner ear antigen (CIEAg). The immunized cochleas and normal control cochleas were examined for the expression of hsp70 by immunohistochemical analysis and in situ hybridization. It was found that 10 of 28 ears showed significant increases in hearing thresholds after the animals had been sensitized with CIEAg, and 67.9% of the ears from the immunized animals had modiolar vasculitis. The hsp70-like proteins were basically expressed in the normal cochleas, but dramatically increased expressions of hsp70 (perhaps also including hsp70-like molecules) and its messenger RNA were observed in the cochleas of the AIED models. The results suggest that the immune response of the inner ear induced the expression of hsp70 in the guinea pig cochleas.

References

Sep 1, 1979·The Annals of Otology, Rhinology, and Laryngology·B F McCabe
Jul 15, 1992·Experientia·C BurelM Morange
Mar 1, 1993·The Laryngoscope·S Yamanobe, J P Harris
Dec 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M Y CaoJ P Tomasi

❮ Previous
Next ❯

Citations

Dec 13, 2019·International Journal of Audiology·Haúla F HaiderLuís-Miguel Borrego
Apr 2, 2015·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Yukihide MaedaKazunori Nishizaki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.