Abstract
Abnormal hyperactivation of the hedgehog (Hh) pathway has been reported in many types of human cancers, including lung cancer. However, most reports are based on studies of fewer than three Hh target genes and the data vary between different studies. In the present report, we have determined the expression levels of several important components of the Hh pathway in lung cancers by using RT-PCR, in situ hybridization and immunohistochemistry. These molecules include Smoothened (SMO), Rab23, the downstream target platelet-derived growth factor receptor alpha (PDGFRα), hedgehog interacting protein (HIP) and hepatocyte nuclear factor 3-beta (HNF3β). Our data show that some components of the hedgehog pathway, such as SMO, Rab23 and PDGFRα are expressed in many lung cancer specimens, although other hedgehog target genes are infrequently detected in lung cancer. Loss of HIP expression was found in several cases of lung cancers. Our study indicates that there might be some additional mechanisms involved in the hyperactivation of the Hh pathway. Thus, we suggest that lung cancer with heterogeneous tumor type harboring Hh signaling activation may have some novel and different regulatory mechanisms.
References
Jan 9, 1998·Nature·J XieF J de Sauvage
May 12, 2001·The Journal of Investigative Dermatology·J M BonifasE H Epstein
Jul 13, 2001·Nature·J T EggenschwilerK V Anderson
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·J XieF McCormick
May 8, 2003·Cell Cycle·D Neil WatkinsStephen B Baylin
Nov 18, 2003·Traffic·Timothy M EvansCarol Wicking
Mar 17, 2004·The Journal of Experimental Medicine·Annika VogtErvin H Epstein
Aug 6, 2004·BMC Cancer·Catherine L OlsenAlan R Brooks
Aug 10, 2004·Journal of Mammary Gland Biology and Neoplasia·Michael T Lewis, Jacqueline M Veltmaat
Jul 9, 2005·International Journal of Cancer. Journal International Du Cancer·Xiaoli MaJingwu Xie
Dec 13, 2005·Development·Danwei Huangfu, Kathryn V Anderson
Dec 21, 2005·Developmental Biology·Jonathan T EggenschwilerKathryn V Anderson
Feb 1, 2006·Cancer Letters·Sumin ChiJingwu Xie
Feb 8, 2006·Journal of Neuroscience Research·Anchen GuoBor Luen Tang
Mar 25, 2006·Future Oncology·Jingwu Xie
Apr 26, 2006·Respirology : Official Journal of the Asian Pacific Society of Respirology·Vincent C DanielD Neil Watkins
May 17, 2006·Surgery·Richard DouardSylvain Loric
Jul 13, 2006·Gastroenterology·Masahide FukayaHiroki Sasaki
Aug 3, 2006·Experimental Dermatology·Mohammad AtharArianna L Kim
Oct 26, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marie EvangelistaFrederic J de Sauvage
Jan 2, 2007·Current Biology : CB·Virginie ClementAriel Ruiz i Altaba
Mar 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yu-Zhen FengIkuo Konishi
Feb 10, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ioannis P GialmanidisHelen Papadaki
Apr 16, 2009·Cancer Research·Ultan McDermottJeffrey Settleman
Citations
May 23, 2013·Infectious Agents and Cancer·Syed Hassan Abbas NaqviSyed Mumtaz Ali Naqvi
Jan 11, 2013·International Journal of Molecular Sciences·Joanna SzkanderaMartin Pichler
Jun 5, 2012·Experimental Cell Research·Swayamsiddha KarSamir Kumar Patra
Mar 6, 2015·Pathology Oncology Research : POR·Redha Al-BahraniConsolato Sergi
Mar 1, 2012·Cellular Signalling·Sumin ChiJingwu Xie
Jan 28, 2015·British Journal of Cancer·G KayserA Zur Hausen
Jan 7, 2015·Archives of Toxicology·Yanfei JiaJingwu Xie
Jul 28, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yanan ChenBor Luen Tang
Apr 27, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Miroslava DidiasovaMalgorzata Wygrecka
Dec 31, 2015·Oncotarget·Qiang JianChengxin Li
Sep 26, 2012·Molecular Medicine Reports·Hai-Ji SunShu-Hong Huang
Feb 11, 2014·Oncotarget·Justina McEvoyMichael A Dyer
Jan 21, 2017·Bioscience Reports·Li-Qiang ZhengCheng-Xin Li
Jul 3, 2015·Journal of Cell Science·Yi Shan Lim, Bor Luen Tang