Expression of hemokinin 1 mRNA by murine dendritic cells

Journal of Neuroimmunology
Daniel A NelsonK L Bost

Abstract

Hemokinin 1 is encoded by preprotachykinin C (PPT-C) mRNA, and has been proposed as a regulator of B and T cell lymphopoiesis. Here we demonstrate the expression of mouse PPT-C mRNA by CD11b+ macrophages, CD11c+ dendritic cells and in the microglial cell line EOC 13.31. Expression was detected in freshly isolated CD11b+CD11c+ bone marrow cells, as well as in M-CSF expanded bone marrow-derived macrophages and GM-CSF expanded bone marrow-derived dendritic cells. There was preferential expression of PPT-C mRNA in dendritic cell subpopulations that were CD11b+, but not B220+ or GR-1+. These studies are the first to demonstrate PPT-C mRNA expression by cells of the myeloid lineage.

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Citations

May 26, 2005·Journal of Neuroimmunology·Alexandra Berger, Christopher J Paige
May 31, 2012·Infectious Agents and Cancer·Vinita S ChauhanKenneth L Bost
Oct 6, 2009·Life Sciences·Alexandra BergerChristopher J Paige
Dec 17, 2008·Neuropeptides·Anne H TranChristopher J Paige
Feb 19, 2008·Brain, Behavior, and Immunity·Daniel A NelsonKenneth L Bost
Sep 29, 2007·Journal of Neuroimmunology·Daniel A NelsonKenneth L Bost
Jul 29, 2008·British Journal of Pharmacology·T MatsumuraH Suzuki
Nov 26, 2010·Annals of the New York Academy of Sciences·Steven D Douglas, Susan E Leeman
Jun 13, 2012·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Akira MakinoHidenori Suzuki
Dec 20, 2005·Cellular Immunology·Daniel A Nelson, Kenneth L Bost
Jan 19, 2018·Journal of Leukocyte Biology·Sergei SpitsinSteven D Douglas
Aug 25, 2015·Biopolymers·Anjali Ganjiwale, Sudha M Cowsik
Feb 21, 2006·Archives of Virology·N Gasper-SmithK L Bost
Jan 3, 2014·Physiological Reviews·Martin S SteinhoffNigel W Bunnett
Mar 3, 2020·Journal of Cellular Biochemistry·Sahar KhorasaniSeyed Isaac Hashemy
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nancy Gasper-SmithKenneth L Bost
Feb 6, 2017·Mediators of Inflammation·Lila CarnigliaMercedes Lasaga
Mar 9, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei WangYu Zhang

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