PMID: 9168858Jun 1, 1997Paper

Expression of heparan sulphate and small dermatan/chondroitin sulphate proteoglycans in chronically inflamed human periodontium

Journal of Dental Research
O OksalaH Larjava

Abstract

Proteoglycans (PGs) function in regulating aspects of cell behavior, such as proliferation, adhesion, and migration. In this report, we investigated the localization of three heparan sulphate PGs (basement membrane [BM] heparan sulphate PG, CD44, and syndecan-1) and two small dermatan/chondroitin sulphate PGs (decorin and biglycan) in chronically inflamed human periodontium. Frozen sections were analyzed by immunofluorescence microscopy. In inflamed tissue, BM heparan sulphate PG showed reduced immunostaining in subepithelial and subendothelial basement membrane. Loss of CD44 and syndecan-1 was common in epithelial cells of inflamed periodontal tissue. Suprabasal keratinocytes of epithelium expressed involucrin, a cornified envelope protein and marker for epithelial differentiation, while the expression of syndecan-1 was weak or absent. In contrast, expression of the mesenchymal variant of CD44 and syndecan-1 was strong in infiltrating lymphocytes. Small dermatan/chondroitin sulphate PGs, decorin and biglycan, were also present in markedly reduced amounts in the periodontal connective tissue in chronic inflammation. In addition, decorin localized in the connective tissue along short rod-like structures. The results suggest that...Continue Reading

References

Nov 1, 1979·Journal of Periodontal Research·G EmberyJ B Stanbury
May 15, 1992·The Biochemical Journal·H LarjavaF Rahemtulla
Jan 1, 1991·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·V J Uitto, H Larjava
Jan 1, 1992·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·F Rahemtulla
Feb 1, 1992·The Journal of Cell Biology·S Jalkanen, M Jalkanen
Mar 8, 1991·Cell·E Ruoslahti, Y Yamaguchi
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M C KieferP J Barr
Nov 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P BiancoP G Robey
Nov 1, 1989·Cell Regulation·R D SandersonM Bernfield
Nov 1, 1987·Journal of Periodontal Research·P M Bartold
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·T Krusius, E Ruoslahti
Dec 27, 1983·Biochimica Et Biophysica Acta·D T WoodleyH K Kleinman
Jan 1, 1984·Archives of Oral Biology·J A PurvisW M Oliver
Feb 1, 1995·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·O OksalaH Larjava
May 1, 1995·Journal of Clinical Periodontology·A J SmithG Embery
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K WirthM Zöller
Jan 1, 1994·EXS·H KresseE Schönherr
Nov 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L HäkkinenH Larjava
Mar 1, 1993·Journal of Periodontology·W V GiannobileC M Cobb
May 15, 1993·Experientia·R Timpl
Jan 1, 1996·Journal of Clinical Periodontology·V J UittoH Larjava

❮ Previous
Next ❯

Citations

Oct 23, 2013·Biochemical Pharmacology·Manuel Gómez-FloritMarta Monjo
Aug 29, 2013·BioMed Research International·Angélica M GomesMauro S G Pavão
May 19, 2005·Journal of Periodontology·Rubia A DiasMasaki Yanagishita
Feb 20, 2014·Journal of Periodontology·Manuel Gómez-FloritJoana M Ramis
Sep 2, 2014·BMC Oral Health·Sakornrat KhongkhunthianSuttichai Krisanaprakornkit
Sep 17, 2013·Brazilian Oral Research·Monique Saveriano de BenedettoMarcelo José Strazzeri Bönecker
Jan 14, 2005·Journal of Cellular Physiology·Elisoa AndrianMahmoud Rouabhia
Apr 1, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Martin Götte
Jan 5, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·L HäkkinenH Larjava
May 1, 2015·Clinical Advances in Periodontics·Andreas O ParashisKonstantinos Tosios
Nov 20, 2020·Journal of Periodontal Research·Priscila A GiovaniKamila R Kantovitz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Clinical Medicine : Journal of the Royal College of Physicians of London
Thomas W Lavender, Brendan McCarron
The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Atsuko YonedaHinke A B Multhaupt
© 2021 Meta ULC. All rights reserved