Expression of hepatitis C virus proteins does not interfere with major histocompatibility complex class I processing and presentation in vitro

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Darius MoradpourA Cerny

Abstract

Hepatitis C virus (HCV) infection takes a chronic course in the majority of patients. The mechanisms underlying the evasion of the host immune response and viral persistence are poorly understood. In this context, we investigated interactions of HCV proteins with major histocompatibility complex (MHC) class I processing and presentation pathways using cell lines that allow the tetracycline-regulated expression of viral structural and nonstructural proteins. These well-characterized inducible cell lines were found to efficiently process and present endogenously synthesized HCV proteins via MHC class I. Functional MHC class I cell-surface expression and intracellular proteasome activity were not affected by the expression of HCV proteins. These results suggest that viral evasion of the host immune response does not involve interactions of HCV with MHC class I processing and presentation. Other mechanisms, such as interference with the interferon system, may be operative in HCV infection, leading to viral persistence.

Citations

Jul 31, 2004·Current Allergy and Asthma Reports·Eric W Hewitt, Gillian E Dugan
May 6, 2003·Gastroenterology·Antonello Pietrangelo
Dec 14, 2001·Molecular Immunology·I P HunzikerA Cerny
Jul 20, 2002·The Lancet Infectious Diseases·Lbachir BenMohamedAnthony B Nesburn
Jan 24, 2007·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Jonathan LarkinSeng-Lai Tan
Nov 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hideki AizakiTetsuro Suzuki
Feb 18, 2011·Journal of Gastroenterology·Angela Dolganiuc, Gyongyi Szabo
Oct 13, 2015·International Journal of Molecular Sciences·Pil Soo SungSeung Kew Yoon
Jan 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keyur PatelJohn G McHutchison
Oct 19, 2004·Annual Review of Microbiology·Naglaa H ShoukryChristopher M Walker
Aug 31, 2002·Virology·Päivi KeskinenIlkka Julkunen
Aug 14, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Pam KimballMitchell Shiffman
Jul 23, 2003·The American Journal of Gastroenterology·Manuel Romero-GómezJosé Aguilar-Reina
Jun 26, 2004·Journal of Leukocyte Biology·Ali Ahmad, Fernando Alvarez
Mar 26, 2003·Cell Death and Differentiation·C WillbergP Klenerman
May 19, 2006·The Journal of Biological Chemistry·Gunter SchmidtkeMarcus Groettrup
May 26, 2005·The Journal of General Virology·Benno WölkDarius Moradpour

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.