Expression of HER1/EGFR protein in human soft tissue sarcomas

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
J-L YangP J Crowe

Abstract

To measure epidermal growth factor receptor (HER1/EGFR) expression in a range of soft tissue sarcoma (STS) patient samples. HER1/EGFR expression was examined by immunohistochemistry in archival tissues of 46 STS patients. HER1/EGFR was positively expressed in 36/46 of STS samples distributed among different histological types. The levels of HER1/EGFR in STS tumour tissues in positive samples were higher compared to those in nearby normal tissues. HER1/EGFR is significantly expressed in soft tissue sarcomas, which is a finding reflected in other series. The significance of this finding for targeted therapy is as yet unknown.

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Citations

Apr 30, 2008·Breast Cancer Research and Treatment·Gary M K TsePuay-Hoon Tan
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