PMID: 11340574May 8, 2001Paper

Expression of HLA class I, beta(2)-microglobulin, TAP1 and IL-10 in Epstein-Barr virus-associated nasal NK/T-cell lymphoma: Implications for tumor immune escape mechanism

International Journal of Cancer. Journal International Du Cancer
L ShenG Srivastava

Abstract

Several mechanisms of immune escape might be in operation in Epstein-Barr virus (EBV)-associated nasal NK/T-cell lymphoma. We have previously shown the downregulation of the immunogenic EBV nuclear antigens by alternative promoter usage and the preferential selection of the deletion genotype of latent membrane protein 1 in nasal lymphoma. To understand further the strategies used for immune escape by this tumor, we examined by immunohistochemistry HLA class I expression in 15 cases using frozen sections, along with beta(2)-microglobulin and transporter associated with antigen processing 1 (TAP1) expression in 39 cases using paraffin sections. All nasal NK/T-cell lymphomas showed positive staining for HLA class I, beta(2)-microglobulin and TAP1 on most tumor cells, except for two cases (5%) in which most of the tumor cells lacked beta(2)-microglobulin staining. We next immunostained for interleukin-10 on frozen sections in 13 cases, all of which showed strong expression by most tumor cells. Transcription of human interleukin-10 but not EBV BCRF1 (viral interleukin-10) was identified by reverse transcriptase-polymerase chain reaction in these nasal NK/T-cell lymphomas. Overall, our data suggest that global downregulation of HLA c...Continue Reading

References

Jan 27, 1995·International Journal of Cancer. Journal International Du Cancer·Q TaoG Srivastava
Apr 15, 1994·International Journal of Cancer. Journal International Du Cancer·H NakagomiM G Masucci
Nov 4, 1996·International Journal of Cancer. Journal International Du Cancer·A K ChiangF C Ho
Mar 11, 2000·Immunology Today·S FerroneG J Nabel
Apr 5, 2000·Molecular Pathology : MP·K R BaumforthP G Murray
Apr 5, 2000·Molecular Pathology : MP·J W HoG Srivastava

❮ Previous
Next ❯

Citations

Feb 8, 2008·International Journal of Hematology·Katsuyuki AozasaWoo-Ick Yang
Nov 7, 2003·Human Immunology·Yasmine SebtiLaurence Amiot
Dec 17, 2002·Critical Reviews in Oncology/hematology·Jaap M MiddeldorpChris J L M Meijer
Dec 7, 2002·Critical Reviews in Oncology/hematology·Shouichi OhgaToshiro Hara
Apr 6, 2007·British Journal of Haematology·Je-Jung LeeYeon Hee Park
Oct 3, 2006·International Journal of Cancer. Journal International Du Cancer·Miki TakaharaEva Klein
Feb 23, 2007·International Journal of Cancer. Journal International Du Cancer·Takeshi OginoSoldano Ferrone
Sep 11, 2012·Journal of Basic Microbiology·Giovanni CaponeDarja Kanduc
Mar 1, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Naoko KanemitsuNorio Komatsu
May 30, 2009·American Journal of Ophthalmology·Pooja V BhatLucia Sobrin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the International Association of Physicians in AIDS Care : JIAPAC
Jennifer LighterWilliam Borkowsky
Frontiers in Bioscience (Scholar Edition)
Joerg WillersAlberta Lucchese
ORL; Journal for Oto-rhino-laryngology and Its Related Specialties
Masayuki FurukawaToshimitsu Kobayashi
Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
V TorreV Cavallari
© 2021 Meta ULC. All rights reserved