Expression of hMSH2 and hMLH1 proteins of the human DNA mismatch repair system in ameloblastoma

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
G CastrilliA Piattelli

Abstract

The human DNA mismatch repair (hMMR) system plays an important role in reducing mutation and maintaining genomic stability. The MMR system in human cells is composed of at least six genes (hMSH2, hMLH1, hMSH3, hPMS1, hPMS2 and GTBP/hMSH6). In particular, hMSH2 and hMLH1 are expressed in human cells that are undergoing rapid renewal; their reduced expression has been reported in several tumors. We examined the protein expression pattern of hMSH2 and hMLH1 by immunohistochemistry in 25 ameloblastomas. All ameloblastomas expressed hMSH2 and hMLH1 proteins in the outer layer of epithelial cells. The localization of the staining was exclusively nuclear. These data suggest that the development and progression of these tumors do not depend on a defect in the hMMR system.

Citations

May 11, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Laurentia NoditJennifer Hunt
Mar 9, 2005·Molecular Carcinogenesis·A BriegerJ Trojan
Jan 25, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·H Kumamoto
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May 11, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Bárbara Vanessa de Brito MonteiroÉricka Janine Dantas da Silveira
Aug 12, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Gleyson Kleber do Amaral-SilvaPablo Agustin Vargas
Jan 30, 2007·The Journal of Biological Chemistry·Yongzhong HouXingming Deng

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