Expression of HNK-1 carbohydrate and its binding protein, SBP-1, in apposing cell surfaces in cerebral cortex and cerebellum

Neuroscience
S M NairF B Jungalwala

Abstract

Sulfoglucuronyl carbohydrate is the terminal moiety of neolacto-oligosaccharides, expressed on several glycoproteins of the immunoglobulin superfamily involved in cell-cell recognition and on two glycolipids. Sulfoglucuronyl carbohydrate is temporally and spatially regulated in the developing nervous system. It appears to be involved in neural cell recognition and in cell adhesion processes through its interaction with specific proteins on cell surfaces. Previously we have characterized a specific sulfoglucuronyl carbohydrate-binding protein in rat brain. Sulfoglucuronyl carbohydrate binding protein-1 is structurally similar to a 30,000 mol. wt adhesive and neurite outgrowth promoting protein amphoterin [Rauvala and Pihlaskari (1987) J. biol. Chem. 262, p. 16,625]. The pattern of expression of sulfoglucuronyl carbohydrate binding protein-1 in developing rat nervous system was studied to understand the significance of its interaction with sulfoglucuronyl carbohydrate-bearing molecules. Biochemical analyses showed that the expression of sulfoglucuronyl carbohydrate binding protein-1 was developmentally regulated similarly to sulfoglucuronyl carbohydrate. Immunocytochemical localization of sulfoglucuronyl carbohydrate binding prot...Continue Reading

References

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Citations

May 15, 2012·Molecular Neurobiology·Ping FangYan-Qin Shen
Apr 25, 2000·Brain Research. Developmental Brain Research·Z ZhaoF B Jungalwala
Sep 12, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·H RauvalaI Kilpeläinen
Aug 28, 2003·Southern Medical Journal·Raphael B Stricker, Edward E Winger
Feb 18, 2005·Journal of Neurochemistry·Kenneth L MoyaLuigi Di Giamberardino
Feb 12, 2004·Journal of Internal Medicine·H J Huttunen, H Rauvala
Oct 24, 2002·The Journal of Biological Chemistry·Alison WoodworthJacques U Baenziger
Jul 9, 1999·Muscle & Nerve·R H Quarles, M D Weiss
Sep 30, 2020·International Journal of Molecular Sciences·Minjuan WangMelitta Schachner

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