Expression of homologues for p53 and p73 in the softshell clam (Mya arenaria), a naturally-occurring model for human cancer

Oncogene
M L KelleyC W Walker

Abstract

Homologues for human p53 (Hsp53) and p73 (Hsp73) genes were cloned and expression patterns for their corresponding proteins analysed in tissues from normal and leukemic softshell clams (Mya arenaria). These are the first structural and functional data for p53 and p73 cDNAs and gene products in a naturally occurring, non-mammalian disease model. Core sequence of the predicted clam p53 (Map53) and p73 (Map73) proteins is virtually identical and includes the following highly conserved regions: the transcriptional activation domain (TAD), MDM2 binding site, ATM phosphorylation site, proline rich domain, DNA binding domains (DBDs) II-V, nuclear import and export signals and the tetramerization domain. The core sequence is a structural mosaic of the corresponding human proteins, with the TAD and DBDs resembling Hsp53 and Hsp73, respectively. This suggests that Map53 and Map73 proteins may function similarly to human proteins. Clam proteins have either a short (Map53) or long (Map73) C-terminal extension. These features suggest that Map53 and Map73 may be alternate splice variants of a p63/p73-like ancestral gene. Map73 is significantly upregulated in hemocytes and adductor muscle from leukemic clams. In leukemic hemocytes, both prote...Continue Reading

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·U M MollA J Levine
Oct 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G ShaulskyV Rotter
Feb 1, 1989·The Journal of Cell Biology·M Kozak
Jan 1, 1989·Journal of Invertebrate Pathology·D L MioskyC L Reinisch
Feb 15, 1987·International Journal of Cancer. Journal International Du Cancer·C Caron de FromentelP May
Mar 1, 1996·Molecular and Cellular Biology·U M MollG Zambetti
Aug 1, 1996·Computer Applications in the Biosciences : CABIOS·R D Page
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·K K Walker, A J Levine
May 1, 1997·Experimental Cell Research·C M BarkerC L Reinisch
Oct 7, 1997·Oncogene·H Schmale, C Bamberger
Oct 23, 1997·Journal of the National Cancer Institute·C L SchlampR W Nickells
Feb 7, 1998·Genes & Development·J D SilicianoM B Kastan
Jun 5, 1998·Bone Marrow Transplantation·K OhnumaH Nishihira
Jul 14, 1998·Nature Medicine·B TrinkD Sidransky
Aug 15, 1998·Biochemical and Biophysical Research Communications·M SenooH Kato
Nov 6, 1998·The Journal of Experimental Medicine·V De LaurenziG Melino
Apr 17, 1999·Molecular and Cellular Biology·X ZengH Lu
May 13, 1999·Oncogene·M DobbelsteinJ Roth
Aug 6, 1999·Oncogene·E BálintK H Vousden
Aug 19, 1999·Protein Science : a Publication of the Protein Society·C D Thanos, J U Bowie
Sep 25, 1999·Journal of Cellular Physiology·T F Burns, W S El-Deiry
Jan 5, 2000·Oncogene·W G Kaelin
Jan 19, 2000·Cell Death and Differentiation·M LevreroJ Y Wang
Jan 19, 2000·Cell Death and Differentiation·S IkawaY Ikawa
Mar 24, 2000·The Veterinary Record·D M WeaverR P Cowart

❮ Previous
Next ❯

Citations

Jun 19, 2008·Journal of Molecular Evolution·Andrew D Fernandes, William R Atchley
Oct 10, 2007·Development Genes and Evolution·Aurora M Nedelcu, Christopher Tan
May 12, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Annette F MuttraySusan A Baldwin
Feb 15, 2002·Journal of Pain and Symptom Management·Patrick J CoyneThomas J Smith
Aug 8, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·R E StephensC L Reinisch
May 12, 2010·Cold Spring Harbor Perspectives in Biology·Wenwei Hu
Jul 3, 2010·Cold Spring Harbor Perspectives in Biology·Rachael RutkowskiAnton Gartner
Jun 3, 2010·Cold Spring Harbor Perspectives in Biology·Vladimir A BelyiArnold J Levine
Jul 23, 2011·Genes & Cancer·Wenwei HuJiabei Wang
Apr 10, 2002·Environmental Health Perspectives·Kathryn Jessen-EllerCarol L Reinisch
Mar 2, 2013·PloS One·Mauro de Freitas RebeloSilvana Allodi
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Ana Goyos, Jacques Robert
Aug 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Osnat Ashur-FabianGideon Rechavi
Oct 12, 2010·Developmental and Comparative Immunology·Ahmed SiahFranck C J Berthe
Apr 27, 2010·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Annette F MuttraySusan A Baldwin
Jul 1, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Mauro StifanićRenato Batel
May 21, 2009·Experimental Gerontology·A G Bodnar
Jan 6, 2009·Gene·Lauren A C HolbrookRebecca J Van Beneden
Nov 1, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Mohamed BanniFrancesco Dondero
Oct 7, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jeanette M RotchellGary K Ostrander
Jul 26, 2008·Marine Environmental Research·Annette F MuttraySusan A Baldwin
Jan 3, 2007·The Veterinary Clinics of North America. Exotic Animal Practice·Arnaud Van Wettere, Gregory A Lewbart
Nov 10, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Rondi A ButlerRebecca J Van Beneden
Jul 7, 2015·Journal of Invertebrate Pathology·María J CarballalAntonio Villalba
May 3, 2006·The American Journal of Pathology·Charles WalkerBen Low
May 6, 2015·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Ana BaričevićRenato Batel
Mar 5, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Cui-Luan Yao, George N Somero
Jun 10, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Helen M BrowningAilsa J Hall
May 1, 2015·Medical Science Monitor Basic Research·Fabio TasceddaEnzo Ottaviani
Mar 29, 2011·Cellular & Molecular Biology Letters·Marta NekulovaBorivoj Vojtesek

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.