PMID: 6159534Sep 18, 1980Paper

Expression of human fibroblast interferon gene in Escherichia coli

Nature
R DerynckW Fiers

Abstract

The human fibroblast interferon gene was inserted in a thermoinducible expression plasmid under control of the phage lambda PL promoter. The primary translation products predicted on the basis of the plasmid constructions were hybrid proteins starting with beta-lactamase or phage MS2 polymerase information followed by the total preinterferon. On induction, antiviral activity, whose physico-chemical, immunological and biological characteristics closely corresponded to those of authentic human fibroblast interferon, was synthesized. Processing to a size compatible with mature but unglycosylated authentic product was observed.

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A KimchiM Revel
Nov 30, 1978·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·R SundmacherD Neumann-Haefelin
Oct 27, 1978·Biochimica Et Biophysica Acta·I Gresser, M G Tovey
Feb 11, 1976·Proceedings of the National Academy of Sciences of the United States of America·E Knight
Aug 1, 1975·Virology·H Greer
Apr 1, 1973·The Journal of General Virology·A BilliauP De Somer
Apr 12, 1980·Lancet·J TreunerP H Hofschneider
Apr 17, 1980·Nature·B R Bloom

❮ Previous
Next ❯

Citations

Aug 6, 2008·Applied Biochemistry and Biotechnology·Dasari Venkata Krishna RaoAdibhatla Kali Satya Bhujanga Rao
Oct 13, 1983·Biochimica Et Biophysica Acta·K SiggensD Burke
Nov 3, 2001·International Journal of Antimicrobial Agents·E De Clercq
Aug 21, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Casey A MaguireMiguel Sena-Esteves
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S Ohno, T Taniguchi
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J P Kraus, L E Rosenberg
Mar 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A J KormanJ L Strominger
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J ContentW Fiers
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D F MarkL S Lin
Jan 1, 1985·Biotechnology & Genetic Engineering Reviews·A Coulson
Sep 1, 1982·The Journal of Experimental Medicine·A D SagarF H Ruddle
Aug 22, 2006·The Journal of Infectious Diseases·Erik De Clercq
Jan 1, 1982·Journal of Interferon Research·E Knight, D Fahey
Jan 1, 1983·Journal of Interferon Research·K G McCullaghM Houghton
Jan 25, 1984·Nucleic Acids Research·R DijkemaH Schellekens
Jan 1, 1988·Journal of Veterinary Internal Medicine·K L Jacobsen, G A Rockwood
Feb 28, 1981·British Medical Journal
Sep 3, 2010·Annual Review of Pharmacology and Toxicology·Erik De Clercq
Sep 30, 1982·Biochimica Et Biophysica Acta·P B Sehgal
Oct 1, 2015·Expert Opinion on Drug Metabolism & Toxicology·Harald HegenFlorian Deisenhammer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.