PMID: 9432079Jan 31, 1998Paper

Expression of human papillomavirus 6 in inverted papilloma arising in a renal transplant recipient

The Laryngoscope
M O HarrisC R Bradford

Abstract

A 36-year-old renal transplant recipient taking cyclosporin A presented with bilateral nasal polypoid lesions involving the nasal septum and lateral nasal walls. Pathologic findings from surgical excision demonstrated inverted papilloma (IP) with focal atypia and mild dysplasia. DNA extracted from the tissue was tested with the polymerase chain reaction (PCR) using human papillomavirus (HPV) E6 and L1 consensus primers. This revealed amplification of the expected size fragment consistent with the presence of HPV DNA. Hybridization of PCR products with HPV type-specific oligonucleotide probes revealed a strong signal with only HPV 6. This result was confirmed by PCR amplification with HPV 6 type-specific primers. RNA extracted from the tissue was subjected to reverse transcription PCR (RT-PCR) with a primer pair specific for viral E6/E7 transcripts. The HPV early proteins, E6 and E7, are the transforming proteins implicated as critical for tumorigenesis. RT-PCR experiments generated products representing the E1/E4 spliced transcript originating from the E6/E6 promoter and a smaller unclassified fragment. These results provide evidence for HPV 6 E6/E7 expression in IP, lending credence to the concept that HPV may play a role in t...Continue Reading

References

Sep 1, 1992·The Laryngoscope·H K KashimaK V Shah
Oct 1, 1992·Experimental and Molecular Pathology·K KitamuraA Okaniwa
Aug 1, 1987·Journal of Virology·L T ChowT R Broker
Jul 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K Vousden

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Citations

Mar 1, 2003·Journal of Clinical Pathology·K J Syrjänen
Dec 1, 2011·Surgical Pathology Clinics·Joaquín J García, Bruce M Wenig
Nov 20, 2012·The Laryngoscope·Kari Syrjänen, Stina Syrjänen

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