Expression of human telomerase reverse transcriptase and correlation with telomerase activity in placentas with and without intrauterine growth retardation

Acta Obstetricia Et Gynecologica Scandinavica
T IzutsuToru Sugiyama

Abstract

Human telomerase reverse transcriptase has been found in telomerase-positive tumor tissues, but not in telomerase-negative nonmalignant somatic cells. Thirty-two first-trimester chorionic villi specimens (Group A), 33 second- and third-trimester placenta specimens without asymmetric intrauterine growth retardation (Group B) and 13 specimens of placenta tissue from cases with intrauterine growth retardation (Group C) were examined for telomerase activity and expression of human telomerase reverse transcriptase by reverse transcription polymerase chain reaction and quantitative reverse transcription polymerase chain reaction. Telomerase activity was detected in 29 of the 32 specimens (90.6%) in Group A, in 20 of the 33 specimens (60.6%) in Group B and none of the 13 specimens (0.0%) in Group C. Human telomerase reverse transcriptase was identified in all 32 specimens of Group A (100%), all 33 specimens of Group B (100%) and 2 of the 13 specimens in Group C (15.4%) by nested reverse transcription polymerase chain reaction. Copy numbers of human telomerase reverse transcriptase were 202.3 +/- 73.0 (n=32), 8.8 +/- 2.9 (n=33) and 0 (n=13) in Groups A, B, and C, respectively. Significant differences were observed between Groups A and ...Continue Reading

Citations

Sep 1, 2015·American Journal of Obstetrics and Gynecology·Rivka Sukenik-HalevyTal Biron-Shental
Oct 20, 2009·Cancer Genetics and Cytogenetics·Rivka Sukenik-HalevyAliza Amiel
Aug 14, 2019·PloS One·Takahito OhiraHiroyuki Kugoh
May 14, 2016·Molecular Medicine Reports·Persefoni FragkiadakiAristides M Tsatsakis

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