Expression of HYAL2 mRNA, hyaluronan and hyaluronidase in B-cell non-Hodgkin lymphoma: relationship with tumor aggressiveness

International Journal of Cancer. Journal International Du Cancer
P BertrandChristian Bastard

Abstract

Hyaluronidases and their substrate, hyaluronan (HA), were mainly explored in solid tumors but rarely in hematologic malignancies. While HA involvement was demonstrated in invasion and metastasis in most cases of solid tumors, the role of hyaluronidases in cancer progression remains controversial. One of the hyaluronidases, HYAL2, is suspected to be involved in the first step of HA degradation. In this work, HYAL2 mRNA, HA and total hyaluronidases expression were examined in lymphoma tissue extracts and correlated to the lymphoma subtype. Real-time RT-PCR was performed to evaluate HYAL2 mRNA. HA and hyaluronidase were assayed by enzyme-linked sorbent assay. Our results showed that HYAL2 mRNA expression was correlated to lymphoma diagnosis (p = 6 x 10(-3)) and was significantly lower in high-grade lymphoma, i.e., diffuse large B-cell diffuse lymphomas (DLBCLs). Several forms of hyaluronidase were detected by zymography and total hyaluronidase activity detected in tissue extracts was not significantly different according to tumor grade. HA levels also correlated to lymphoma subtype (p = 1 x 10(-5)) and were higher in DLBCLs. Moreover, HYAL2 mRNA and HA expressions were inversely correlated (p = 0.035). HYAL2 gene is localized on c...Continue Reading

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Citations

May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Melanie A Simpson, Vinata B Lokeshwar
Oct 18, 2014·Cancer Metastasis Reviews·Anja SchmausJonathan P Sleeman
Aug 19, 2007·Genes, Chromosomes & Cancer·Carole AlmireChristian Bastard
Nov 11, 2006·International Journal of Cancer. Journal International Du Cancer·Katsunori Kyoda
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Apr 4, 2021·Cancers·Zoi PiperigkouNikos K Karamanos

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