PMID: 6166700Mar 1, 1981Paper

Expression of hybrid Ia molecules on the cell surface of reticulum cell sarcomas that are undetectable on host SJL/J lymphocytes

The Journal of Experimental Medicine
S M Wilbur, B Bonavida

Abstract

SJL/J (H-2 (8)) lymphocytes, primed in vitro against primary, cultured, and transplantable syngeneic reticulum cell sarcomas (RCS) were found to recognize and bind to the tumor without subsequent cytolysis. Additional data showed that the recognition was also directed against Ia molecules of the H-2(d), but not H-2(k), haplotype. Normal spleen cells of DBA/2, B 10.D2, and B 10.OL mice were bound, whereas those of CBA, B 10.BR, B 10.A, B 10.GD, and D2.GD were not. Furthermore, the Ia molecules were in the form of a hybrid, because spleen cells from F(1) progeny of a B10.A and a B10.GD parent were recognized and bound as effectively as the RCS. Recognition was not restricted solely to the H-2(d) haplotype. Spleen cells from B10.S(9R) mice were also significantly bound. This result suggested that the RCS expresses a hybrid Ia molecule containing a beta-chain of the H-2(8) haplotype. Recognition of this hybrid Ia molecule by the host resulted in a cross- reactive recognition of H-2(d) specificities. Further analysis revealed that the RCS express on their cell surface an alpha-chain of the hybrid Ia molecule which is involved in host anti-tumor recognition. Preincubation of the RCS with monoclonal antibody directed against the Ia.7 ...Continue Reading

References

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Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M E Dorf, B Benacerraf
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Mar 1, 1980·The Journal of Experimental Medicine·W P LafuseC S David

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Citations

Dec 1, 1989·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J D Katz, B Bonavida
Aug 1, 1989·Journal of Immunogenetics·G Anderson, C David
Jan 1, 1983·Immunological Reviews·J Hors, J Dausset
Jul 1, 1986·International Reviews of Immunology·N M PonzioG J Thorbecke

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