Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors

Journal of Neuropathology and Experimental Neurology
Takahiro FukudaSaburo Saito

Abstract

Pineal parenchymal tumor (PPT) cells usually show immunoreactivity for synaptophysin, neuron-specific enolase, neurofilament protein, class III beta-tubulin, tau protein, PGP9.5, chromogranin, serotonin, retinal S-antigen, and rhodopsin, but these markers are not specific for PPTs. Melatonin is produced and secreted mainly bypineal parenchymal cells; hydroxyindole-O-methyltransferase (HIOMT) catalyzes the final reaction in melatonin biosynthesis. We hypothesized that HIOMT could serve as a tumor marker of PPTs, and we investigated HIOMT localization and HIOMT expression in samples of normal human tissue and in PPTs, primitive neuroectodermal tumors, and medulloblastomas. In normal tissue, HIOMT was expressed in retinal cells, pineal parenchymal cells, neurons of the Edinger-Westphal nucleus, microglia, macrophages, thyroid follicular epithelium, principal and oxyphil cells of parathyroid gland, adrenal cortical cells, hepatic parenchymal cells, renal tubule epithelium, and enteroendocrine cells of stomach and duodenum. The HIOMT was also expressed in all 46 PPTs studied. The proportions of HIOMT-immunoreactive cells successively decreased in the following tumors: pineocytoma, pineal parenchymal tumor of intermediate differentia...Continue Reading

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Citations

Apr 28, 2012·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Alexandru SzathmariMichelle Fèvre Montange
Oct 30, 2015·Journal of Pineal Research·Gabriela S KinkerPedro A Fernandes
Jun 24, 2011·Neuropathology and Applied Neurobiology·M Fèvre-MontangeA Jouvet
Jul 1, 2014·Neuro-Chirurgie·A JouvetM Fèvre Montange
Nov 7, 2017·British Journal of Pharmacology·Regina P MarkusMarina Marçola
Jan 1, 2019·Journal of Pineal Research·Yaoyao XiaWenkai Ren
Jun 5, 2019·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Judith L RossAndrew R Zinn
Apr 30, 2020·Journal of Clinical Medicine·Zongye CaiDaphne Merkus

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