Expression of hypoxia-inducible factor 1α, glucose transporter 1, and hexokinase 2 in primary central nervous system lymphoma and the correlation with the biological behaviors.

Brain and Behavior
Na ShenYuanbo Liu

Abstract

It has been indicated that abnormal glucose metabolism mediated by hypoxia-inducible factor 1α (HIF-1α) played an essential role in the development of solid tumor. However, there were rare studies about the role of them in primary central nervous system lymphoma (PCNSL). To investigate the protein levels of HIF-1α, glucose transporter 1 (GLUT1), and hexokinase 2 (HK2) in PCNSL and whether their levels are associated with prognostic factors. Expression of HIF-1α, GLUT1, and HK2 in 39 tumor tissues was evaluated by immunohistochemical stainning. The correlation of the expression of HIF-1α with the protein level of GLUT1 and HK2 was investigated. In addition, the association between these protein expression levels and clinical parameters and prognosis was analyzed. In the tumor specimens of PCNSL, positive stainings of HIF-1α, GLUT1, and HK2 were in 23 patients (58.97%), 25 patients (64.1%), and 26 patients (66.67%), respectively, which were associated with the expression level of lactic dehydrogenase (LDH), but not with age, gender, number of lesion, ECOG score, or deep structure. The expression of HIF-1α was positively correlated with the expression of GLUT1 (p < .01, r = .749) and HK2 (p < .01, r = .787). Univariate analysis sh...Continue Reading

References

May 30, 2001·Current Opinion in Genetics & Development·P H MaxwellP J Ratcliffe
Sep 25, 2004·Journal of Cellular Physiology·Maria L MachedaJames D Best
Dec 30, 2004·Nature Genetics·Ken InokiKun-Liang Guan
Mar 7, 2006·Cell Metabolism·M Celeste Simon
Mar 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tracy Batchelor, Jay S Loeffler
Jun 7, 2007·Journal of Bioenergetics and Biomembranes·Gregg L Semenza
Jan 10, 2009·Seminars in Cancer Biology·R Brooks Robey, Nissim Hay
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·KangAe LeeGregg L Semenza
Dec 19, 2009·The Journal of Biological Chemistry·Yongjun FanWei-Xing Zong
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Oct 12, 2011·Annual Review of Cell and Developmental Biology·Sophia Y Lunt, Matthew G Vander Heiden
Feb 15, 2012·The Journal of Experimental Medicine·Robert B Hamanaka, Navdeep S Chandel
Dec 24, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jian ChenWeijia Kong
Aug 8, 2014·British Journal of Haematology·James S Blachly, Robert A Baiocchi
Feb 19, 2015·Molecular Biology Reports·Rupert CourtnayTom C Karagiannis
Mar 29, 2016·British Journal of Haematology·Meredith S ShielsEric A Engels
Mar 31, 2017·Acta Oncologica·Sourabh Soni, Yogendra S Padwad

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
light microscopy

Software Mentioned

SPSS

Related Concepts

Related Feeds

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.